To determine the prevalence and antimicrobial susceptibility of Streptococcus pneumoniae in the oropharynx of healthy children, throat swabs were obtained from 683 children and cultured. The disk diffusion method and the E test were used to test the antimicrobial susceptibility of the isolated organisms. Twenty-nine children (4.2%) harbored S. pneumoniae in their oropharynx. Fifteen (51.7%) of the isolates showed intermediate resistance to penicillin and 14 (48.3%) were susceptible. All strains were susceptible to rifampicin and moxifloxacin. One was resistant to telithromycin. The rates of resistance to clindamycin, erythromycin, chloramphenicol and tetracycline were 41.3, 44.8, 34.4, and 44.8%, respectively. Risk factors for S. pneumoniae carriage were also assessed.
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Environ Pollut
January 2025
Department of Environmental Sciences, Southern Illinois University Edwardsville, 44 Circle Drive SW 2145, PO Box 1099, Edwardsville, IL 62026. Electronic address:
The antimicrobial properties and widespread incorporation of silver nanoparticles (AgNPs) into consumer products have raised concerns about their potential impact on public health and the environment. This study examined citrate-coated and uncoated AgNPs' antimicrobial effects on microbial growth and their potential to induce antimicrobial resistance (AMR) in the natural environment. We isolated Pseudomonas aeruginosa and Salmonella spp.
View Article and Find Full Text PDFInt J Antimicrob Agents
January 2025
Pfizer Inc., Bucharest, Romania. Electronic address:
The increasing prevalence of infections due to metallo-β-lactamase (MBL)-producing Enterobacterales poses a serious concern given the limited treatment options available. This systematic literature review (SLR) describes the molecular epidemiology, geographical distribution, and clinical outcomes of such infections. Systematic searches of literature published between January 2013 and May 2023 were performed, and 39 studies with an MBL sample size of ≥25 isolates and ≥2 well-defined outcomes were eligible.
View Article and Find Full Text PDFEnviron Int
January 2025
School of Environment, South China Normal University, University Town, Guangzhou, China. Electronic address:
The extensive use of antibiotics has led to their frequent detection as residues in the environment. However, monitoring of their levels in groundwater and the associated ecological and health risks remains limited, and the impact of river pollution on groundwater is still unclear. This study focused on the highly urbanized Maozhou River and its groundwater.
View Article and Find Full Text PDFClin Microbiol Infect
January 2025
European Society of Clinical Microbiology and Infectious Diseases Study Group on Clostridioides difficile (ESGCD); Experimental Bacteriology Research Group, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
Objectives: Increasing resistance to antimicrobials used for the treatment of Clostridioides difficile infections necessitates reproducible antimicrobial susceptibility testing. Current guidelines take a one-size-fits-all approach and/or offer limited guidance. We investigated how the choice of medium affects measured MIC values across two sites.
View Article and Find Full Text PDFPLoS One
January 2025
Cell Therapy Center, The University of Jordan, Amman, Jordan.
Background: Hypoxia in tumor cells is linked to increased drug resistance and more aggressive behavior. In pancreatic cancer, the tumor microenvironment is notably hypoxic and exhibits strong immunosuppressive properties. Given that immunotherapy is now approved for pancreatic cancer treatment, further understanding of how pancreatic tumor cell hypoxia influences T-cell cytotoxicityis essential.
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