Alexandre Yersin was born in French Switzerland and later took French nationality. While a medical student he worked in Paris with Emile Roux to discover the exotoxin produced by the diphtheria bacillus. Two years after graduation, he left Paris for French Indochina where he was the first European to explore and map the central highlands of Vietnam. As a member of the French Colonial Health Service he was sent to Hong Kong in 1894 to investigate the outbreak of bubonic plague. He isolated from buboes the causative bacillus that later was named Yersinia pestis in his honour. In Vietnam, Yersin established a Pasteur Institute at the coastal village of Nha Trang where he lived for the rest of his life. He developed vaccines and antisera for both men and animals and, as an agronomist, he introduced the Brazilian rubber tree and Peruvian cinchona tree (for quinine) into the country. In Vietnam, as in France, the name of Yersin continues to be venerated.
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http://dx.doi.org/10.1258/jmb.2007.007017 | DOI Listing |
J Mol Biol
March 2010
Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan.
Transferrin receptor 2 (TfR2), a homologue of the classical transferrin receptor 1 (TfR1), is found in two isoforms, alpha and beta. Like TfR1, TfR2alpha is a type II membrane protein, but the beta form lacks transmembrane portions and therefore is likely to be an intracellular protein. To investigate the functional properties of TfR2alpha, we expressed the protein with FLAG tagging in transferrin-receptor-deficient Chinese hamster ovary cells.
View Article and Find Full Text PDFBiophys Chem
September 2009
Laboratory of Biodynamics, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
Glycophorin A (GpA) is one of the most abundant transmembrane proteins in human erythrocytes and its interaction with lectins has been studied as model systems for erythrocyte related biological processes. We performed a force measurement study using the force mode of atomic force microscopy (AFM) to investigate the single molecular level biophysical mechanisms involved in GpA-lectin interactions. GpA was mounted on a mica surface or natively presented on the erythrocyte membrane and probed with an AFM tip coated with the monomeric but multivalent Psathyrella velutina lectin (PVL) through covalent crosslinkers.
View Article and Find Full Text PDFPflugers Arch
April 2008
Laboratory of Biodynamics, Tokyo Institute of Technology, 4259-B8 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.
Adaptation of a cell behavior to the environment is possible due to the biochemical and physical information that is transmitted through molecular receptor present at the cell surface. Regulation of receptor distribution and trafficking is thus a key feature to allow cells to properly respond to extracellular signals. Many of the molecular mechanisms that support receptor trafficking occurs at a submicrometric scale and are highly dynamic.
View Article and Find Full Text PDFBiophys J
February 2008
Cellular Neurobiology Laboratory, Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
Many approaches have been developed to characterize the heterogeneity of membranes in living cells. In this study, the elastic properties of specific membrane domains in living cells are characterized by atomic force microscopy. Our data reveal the existence of heterogeneous nanometric scale domains with specific biophysical properties.
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