AI Article Synopsis
- The study investigates the role of DC-STAMP in dendritic cells (DCs), highlighting its importance in preventing autoimmunity and maintaining self-tolerance.
- Researchers found that aged mice lacking DC-STAMP exhibited systemic autoimmune symptoms, including increased T cell infiltration in various organs and elevated levels of anti-double-stranded DNA antibodies.
- Despite unchanged DC differentiation and proliferation, DCs without DC-STAMP showed enhanced antigen presentation and phagocytic activity, which may contribute to autoimmune responses.
Article Abstract
Regulation of dendritic cell (DC) function is critical for maintaining self-tolerance and preventing autoimmunity. The dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in cell-cell fusion of osteoclasts and foreign body giant cells, but though originally identified in DCs, its specific roles there remain undefined. Here, we report that aged DC-STAMP-deficient mice display several systemic autoimmune symptoms such as spontaneous lymphoproliferation, splenomegaly associated with infiltration of T cells in several organs and increased serum anti-double-stranded DNA antibody production. Although a lack of DC-STAMP did not inhibit DC differentiation or proliferation, antigen presentation activity of DC-STAMP-deficient DCs was significantly up-regulated in both class I and II pathways through increased phagocytotic activity compared with wild-type DCs, an activity likely leading to autoimmunity. Our results indicate that DC-STAMP is required for proper regulation of DC activity and maintenance of immune self-tolerance.
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| http://dx.doi.org/10.1093/intimm/dxn082 | DOI Listing |
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