Relationship between developmental synaptic modulation and conditioning-induced synaptic change in Lymnaea.

Acta Biol Hung

Graduate School of High-Technology for Human Welfare, Tokai University, 317 Nishino, Numazu 410-0321, Shizuoka, Japan.

Published: September 2008

Though adult Lymnaea are bimodal breathers, young animals breathe mainly through the skin and adults through the lung. Operant conditioning changes adult breathing behavior from aerial to cutaneous. We hypothesized that this behavioral change is caused by alterations in the neuronal circuit during both development and conditioning. We focused our study on whether the synaptic connection between RPeD1 and RPA6 neurons is modulated during development and conditioning. Our findings indicated that the RPeD1 has an excitatory monosynaptic contact with the RPA6 in young naive and operantly-conditioned adult animals. The relationship of this contact was well correlated with their respiratory behavior.

Download full-text PDF

Source
http://dx.doi.org/10.1556/ABiol.59.2008.Suppl.15DOI Listing

Publication Analysis

Top Keywords

development conditioning
8
relationship developmental
4
developmental synaptic
4
synaptic modulation
4
modulation conditioning-induced
4
conditioning-induced synaptic
4
synaptic change
4
change lymnaea
4
lymnaea adult
4
adult lymnaea
4

Similar Publications

Background Aims: Extracellular vesicles (EVs) have gained traction as potential cell-free therapeutic candidates. Development of purification methods that are scalable and robust is a major focus of EV research. Yet there is still little in the literature that evaluates purification methods against potency of the EV product.

View Article and Find Full Text PDF

CNPY2 modulates senescence-associated secretory phenotype in tendon stem/progenitor cells.

Tissue Cell

December 2024

Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. Electronic address:

Age-related diseases are often linked to chronic inflammation. Senescent cells secrete inflammatory cytokines, chemokines and matrix metalloproteinases, collectively referred to as the senescence-associated secretory phenotype (SASP). The current study discovered that aging leads to the accumulation of senescent tendon stem/progenitor cells (TSPCs) in tendon tissue, resulting in the development of a SASP.

View Article and Find Full Text PDF

Rationale: Clinical literature indicates there may be a therapeutic use of cannabidiol (CBD) for stress-related disorders. Preclinical literature remains conflicted regarding the underlying neurobehavioral mechanisms, reporting mixed effects of CBD (increased, decreased, or no effect) on anxiety- and fear-related behaviors. Preclinical data demonstrated that CBD modulates hypothalamus-pituitary-adrenal (HPA) axis gene expression; it is unknown whether CBD changes HPA axis responsivity and how this relates to altered behavior.

View Article and Find Full Text PDF

Size exclusion chromatography-gradient (SEC-Gradient) is a powerful technique to separate polymers by their chemical composition. The stationary phase is first conditioned with a gradient from adsorli to desorli, and polymer samples are injected after the gradient in SEC conditions. Since its first description in 2011 by Schollenberger and Radke, it has never been applied to block copolymers.

View Article and Find Full Text PDF

IR-Driven Multisignal Conditioning for Multiplex Detection: Thermal-Responsive Triple DNA-Mediated Reconfigurable Photoelectrochemical/Photothermal Dual-Mode Strategy.

ACS Sens

January 2025

College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Changchun 130012, China.

Article Synopsis
  • This research introduces a new integrated multitarget photoelectrochemical sensor that simplifies real-time detection by removing the need for complex equipment and time-consuming procedures.
  • The method uses infrared-driven "four-to-one" multisignal conditioning to dynamically adapt the electrode interface for detecting multiple targets simultaneously, specifically utilizing copper sulfide quantum dots for improved signal generation.
  • The sensor's effectiveness is demonstrated by successfully identifying the presence of antibiotics in real samples, showcasing its potential for rapid and eco-friendly applications in environmental, medical, and food safety testing.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!