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G-quadruplex-forming aptamer enhances the peroxidase activity of myoglobin against luminol.
Nucleic Acids Res
June 2021
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Aptamers can control the biological functions of enzymes, thereby facilitating the development of novel biosensors. While aptamers that inhibit catalytic reactions of enzymes were found and used as signal transducers to sense target molecules in biosensors, no aptamers that amplify enzymatic activity have been identified. In this study, we report G-quadruplex (G4)-forming DNA aptamers that upregulate the peroxidase activity in myoglobin specifically for luminol.
View Article and Find Full Text PDFMyoglobin promotes nitrite-dependent mitochondrial S-nitrosation to mediate cytoprotection after hypoxia/reoxygenation.
Nitric Oxide
November 2020
Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA. Electronic address:
It is well established that myoglobin supports mitochondrial respiration through the storage and transport of oxygen as well as through the scavenging of nitric oxide. However, during ischemia/reperfusion (I/R), myoglobin and mitochondria both propagate myocardial injury through the production of oxidants. Nitrite, an endogenous signaling molecule and dietary constituent, mediates potent cardioprotection after I/R and this effect relies on its interaction with both myoglobin and mitochondria.
View Article and Find Full Text PDF[Clinicopathologic features and immunophenotype of pseudosarcomatous myofibroblastic proliferation of urinary bladder].
Zhonghua Bing Li Xue Za Zhi
August 2018
Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
To investigate the clinicopathologic features, immunohistochemical phenotypes and biological behavior of pseudosarcomatous myofibroblastic proliferation (PMP) of the urinary bladder which may be misdiagnosed as a malignant neoplasm and undergo extensive treatment. Six cases of PMP of the urinary bladder were collected from 2001 to 2016 at Beijing Tiantan Hospital, Capital Medical University. The clinicopathologic features and immunophenotypic profile were studied by histopathological and immunohistochemical investigations with clinical follow-up.
View Article and Find Full Text PDF[Myoglobin: still a useful biomarker in 2017?].
Ann Biol Clin (Paris)
April 2018
Hôpital d'instruction des armées Bégin, Département des laboratoires, Saint Mandé, France, École du Val-de-Grâce, Paris, France.
The clinical biologist plays a role as a consultant for the relevant use of biological examination. Advisory activities of the medical laboratory may help physician in diagnosis or therapeutic algorithm, avoiding redundant ordering or useless tests. In this context, we performed a review of literature about the clinically interest of myoglobin assays.
View Article and Find Full Text PDFIntracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion.
Physiol Rep
January 2017
Faculty of Human Sciences, Kanazawa University, Kanazawa, Japan
Under acute hypoxic conditions, the muscle oxygen uptake (mV˙O) during exercise is reduced by the restriction in oxygen-supplied volume to the mitochondria within the peripheral tissue. This suggests the existence of a factor restricting the mV˙O under hypoxic conditions at the peripheral tissue level. Therefore, this study set out to test the hypothesis that the restriction in mV˙O is regulated by the net decrease in intracellular oxygen tension equilibrated with myoglobin oxygen saturation (∆PO) during muscle contraction under hypoxic conditions.
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