AI Article Synopsis
Article Abstract
Lipopolysaccharide (LPS) treatment of Peripheral Blood Mononuclear Cells (PBMC) isolated from the water buffalo resulted in the activation of TLR signaling intermediates as supported by the western blot of pERK. Activation of ERK resulted in phosphorylation of IkappaB-alpha which lead to its degradation which in turn followed by nuclear translocation of NF-kappaB, which is also supported by the western blot analysis. The nuclear translocation of NF-kappaB culminated in the induction of mRNA expression of TNF-alpha. Thus this study demonstrates the TLR signaling in PBMCs of water buffalo which is as similar to that reported earlier in mice and human beings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11259-008-9074-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Global foot-and-mouth disease risk assessment based on multiple spatial analysis and ecological niche model.
Vet Q
December 2025
College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Foot-and-Mouth Disease is a highly contagious transboundary animal disease. FMD has caused a significant economic impact globally due to direct losses and trade restrictions on animals and animal products. This study utilized multi-distance spatial cluster analysis, kernel density analysis, directional distribution analysis to investigate the spatial distribution patterns of historical FMD epidemics.
View Article and Find Full Text PDFSubstrate curvature influences cytoskeletal rearrangement and modulates macrophage phenotype.
Front Immunol
January 2025
Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, United States.
Introduction: Inflammation is a vital immune response, tightly orchestrated through both biochemical and biophysical cues. Dysregulated inflammation contributes to chronic diseases, highlighting the need for novel therapies that modulate immune responses with minimal side effects. While several biochemical pathways of inflammation are well understood, the influence of physical properties such as substrate curvature on immune cell behavior remains underexplored.
View Article and Find Full Text PDFComparative evaluation of protective efficacy of experimental inactivated vaccines against haemorrhagic septicaemia.
Braz J Microbiol
January 2025
ICAR - Indian Veterinary Research Institute, Bengaluru, 560 024, Karnataka, India.
Developing an effective vaccine for haemorrhagic septicaemia (HS) in cattle and buffaloes is urgently needed. While preferred for their safety, achieving sufficient, cross-protective, and long-lasting immunity is still challenging when administering inactivated vaccines. This study aimed to assess the efficacy of four inactivating components comprising three inactivating agents: (1) Binary ethylenimine (BEI), (2) Formalin, (3) a combination of BEI and Formalin, and (4) Hydrogen peroxide (HO), in inactivating Pasteurella multocida to enhance HS vaccine potency.
View Article and Find Full Text PDFFish as environmental sentinels for metal contaminants of human health concern in the Lower Mississippi River Basin.
J Trace Elem Med Biol
January 2025
The Department of Chemistry and Biochemistry, Mississippi College, Clinton, MS, United States.
Industrial expansion and population growth have lowered water quality, polluting aquatic ecosystems world-wide. Metal pollution in the rivers across the United States are a major health concern. The level of metal contamination in fish from the Lower Mississippi River Basin and their threat to public health were last evaluated 20 years ago.
View Article and Find Full Text PDF3'-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine.
Int J Parasitol Drugs Drug Resist
January 2025
Laboratory of Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp, 2610, Wilrijk, Belgium. Electronic address:
Surra and Dourine are widespread diseases caused by two protozoan parasites Trypanosoma brucei evansi and Trypanosoma brucei equiperdum, respectively. A wide range of animals including camels, horses, cattle and buffaloes are susceptible to infection. These diseases pose a significant socio-economic burden, primarily due to the limited therapeutic options and the complications associated with toxicity and drug resistance, making disease management particularly challenging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!