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Tracing ALS Degeneration: Insights from Spinal Cord and Cortex Transcriptomes.
Genes (Basel)
November 2024
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, Tamilnadu, India.
Background/objectives: Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by the loss of upper and lower motor neurons. Key factors contributing to neuronal death include mitochondrial energy damage, oxidative stress, and excitotoxicity. The frontal cortex is crucial for action initiation, planning, and voluntary movements whereas the spinal cord facilitates communication with the brain, walking, and reflexes.
View Article and Find Full Text PDFBilateral tDCS over the DLPFC enhances baroreceptor reflex sensitivity and inhibits blood pressure-related hypoalgesia.
Clin Neurophysiol
January 2025
University of Jaén, Department of Psychology, Spain.
Objective: This study investigated the impact of transcranial direct stimulation (tDCS) on pain perception, baroreflex sensitivity (BRS), and blood pressure (BP)-related hypoalgesia.
Method: Fifty-eight healthy participants were randomized to receive 1) bi-hemispheric tDCS over the dorsolateral prefrontal cortex (DLPFC) at 2 mA for 20 min, or 2) non-stimulation (Sham). Pain measures (threshold, tolerance, intensity and unpleasantness), emotional state (anxiety and mood), continuous BP, and electrocardiogram (ECG) data were recorded before, during, and after stimulation.
Determinants of time-to-recovery from hypertension by application of Weibull-Inverse Gaussian shared frailty model.
Pan Afr Med J
November 2024
School of Public Health, Bahir Dar University, Bahir Dar, Ethiopia.
Introduction: hypertension is a major public health problem that is responsible for mortality. In Ethiopia, hypertension is becoming a double burden due to urbanization. The study aims to identify factors that affect the time to recovery from hypertension.
View Article and Find Full Text PDFInteractive molecular causal networks of hypertension using a fast machine learning algorithm MRdualPC.
BMC Med Res Methodol
August 2024
Centre for Biostatistics, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.
Background: Understanding the complex interactions between genes and their causal effects on diseases is crucial for developing targeted treatments and gaining insight into biological mechanisms. However, the analysis of molecular networks, especially in the context of high-dimensional data, presents significant challenges.
Methods: This study introduces MRdualPC, a computationally tractable algorithm based on the MRPC approach, to infer large-scale causal molecular networks.
Does home blood pressure monitoring improve blood pressure-related outcomes in people living with chronic kidney disease? A systematic review.
J Clin Hypertens (Greenwich)
April 2024
Leicester Diabetes Centre, University of Leicester, Leicester, UK.
High blood pressure is an important risk factor for cardiovascular disease and disease progression in chronic kidney disease (CKD). Evidence on the effects of home blood pressure monitoring (HBPM) is limited. This review aimed to determine the effect of HBPM on systolic (SBP) and diastolic blood pressure (DBP) in patients with CKD.
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