AI Article Synopsis
- A 72-year-old man experienced severe oral bleeding due to an acquired factor V inhibitor affecting his blood clotting.
- Laboratory tests showed extreme abnormalities in prothrombin and activated partial thromboplastin times, very low factor V activity, and decreased levels of Factors II and X.
- Treatment with prednisolone successfully stopped the bleeding and improved his blood coagulation, highlighting that high levels of factor V inhibitor can influence coagulation tests despite normal factor activity.
Article Abstract
A 72-year-old male presented with oral bleeding resulting from acquired factor V (FV) inhibitor. We observed abnormalities in prothrombin time (PT) (8%) and activated partial thromboplastin time (APTT) (>200 seconds). FV activity was less than 3%, and a mixing test did not correlate with PT. FV inhibitor assay demonstrated 240 Bethesda units/ml. The patient also showed markedly decreased activity of Factors II (13%) and X (14%). Oral bleeding disappeared and coagulation abnormalities improved with prednisolone therapy. High titer FV inhibitor might affect coagulation assays even in a patient with normal factor activity.
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