Background: The high rate of alcohol use among emergency department (ED) patients makes the ED setting an obvious target for increased screening and interventions. However, interventions to change alcohol behavior may be applied inappropriately if a patient's motivation to change is not factored in. In this study, we identify correlates of readiness to change problem drinking among a sample of ED patients with problem drinking.
Method: Cross-sectional study of 295 ED patients who scored positive for alcohol problems on the CAGE questionnaire (score > or = 1). Study measures include illicit drug use, exposure to violence, and having a primary care doctor as the main predictor variables and level of readiness to change problem drinking as the outcome measure.
Results: Participants were 64% African American, 30% Latino, and 80% male; 46% had less than a high school diploma; 85% were not married; 72% had no health insurance; and 85% had no primary care provider. Whereas 12% of patients were not ready to change their drinking behaviors, 47% and 41% were unsure and ready, respectively. Multiple linear regression analysis showed that only the use of illicit drugs significantly affected the likelihood of changing one's level of readiness-to-change problem drinking (P < .05). Female and married participants were also more likely to be ready to change their alcohol use behaviors.
Conclusions: Recognizing that approximately half of ED patients with problem drinking are ambivalent to changing their behaviors supports further investigation into specific clinical interventions aimed at motivating such individuals along the continuum of readiness to change. Such interventions should also incorporate strategies for addressing the co-occurrence of illicit substance use.
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Mol Psychiatry
January 2025
Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.
The hypothalamic neuropeptide system of orexin (hypocretin) neurons provides projections throughout the neuraxis and has been linked to sleep regulation, feeding and motivation for salient rewards including drugs of abuse. However, relatively little has been done to examine genes associated with orexin signaling and specific behavioral phenotypes in humans. Here, we tested for association of twenty-seven genes involved in orexin signaling with behavioral phenotypes in humans.
View Article and Find Full Text PDFInt J Pharm
January 2025
Center for New Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006 China; Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, Guangdong Pharmaceutical University, Guangzhou 510006 China; Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006 China. Electronic address:
Disulfiram (DSF), which has been traditionally used to treat alcoholism, has been shown to inhibit tumor growth, indicating its potential as an anticancer agent. However, its development and application are hindered by its poor water solubility, instability in physiological environments, and low bioavailability. In this study, phenylboronic acid-chitosan (PBA-CS) grafts were synthesized using the carbodiimide method.
View Article and Find Full Text PDFCien Saude Colet
January 2025
Instituto René Rachou, Fundação Oswaldo Cruz (Fiocruz Minas). Av. Augusto de Lima 1715, Barro Preto. 30190-002 Belo Horizonte MG Brasil.
This integrative review systematized the factors that influence access to mental health services for the Homeless Population (HP) in harmful use of alcohol and other drugs in the Psychosocial Care Network (RAPS) in Brazil by categorizing the factors into access "barriers" and "facilitators". We selected 13 corresponding articles and subsequently assessed their methodological quality. We identified 19 access barriers and 22 access facilitators, observing a convergence and complementarity of the factors identified, with no disagreements between authors.
View Article and Find Full Text PDFIDCases
January 2025
University of Kansas Medical Center, Department of Internal Medicine, Division of Infectious Diseases, 3901 Rainbow Blvd., Mailstop 1028, Kansas City, KS 66160, USA.
() was first isolated from the larval stage of the fly vector It is a gram-negative, non-motile, strictly aerobic rod that thrives in temperatures between 28º C and 37º C. Its strong chitinase activity aids in metamorphosis, which suggests a symbiotic relationship with the fly. Although rare, has been implicated in human infections, like bacteremia and osteomyelitis, typically transmitted through fly larvae in skin wounds.
View Article and Find Full Text PDFJDS Commun
January 2025
Animal Welfare Program, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Water is an essential resource for dairy cows, and its consumption is closely linked to feed intake. Social competition can lead to changes in drinking behavior, especially for subordinate cows. We studied how changes in stocking density at the feeder (1 or 2 cows per feeder), and drinker (6 or 12 cows per drinker) and a temporal feed restriction (14- or 24-h access) affects drinking in 4 groups of 6 cows each, following a Latin square design.
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