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Prospective validation study of a combined urine and plasma test for predicting high-grade prostate cancer in biopsy naïve men.
Scand J Urol
January 2025
Department of Urology, Odense University Hospital, Odense, Denmark; Academy of Geriatric Cancer Research (AgeCare), Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Objective: Early and accurate diagnosis of prostate cancer (PC) is crucial for effective treatment. Diagnosing clinically insignificant cancers can lead to overdiagnosis and overtreatment, highlighting the importance of accurately selecting patients for further evaluation based on improved risk prediction tools. Novel biomarkers offer promise for enhancing this diagnostic process.
View Article and Find Full Text PDFEffect of Reaction Interface Structure on the Morphology and Performance of Thin-Film Composite Membrane.
Environ Sci Technol
January 2025
Jiangsu Key Laboratory of Anaerobic Biotechnology, School of Environment and Ecology, Jiangnan University, Wuxi 214122, PR China.
Thin-film composite (TFC) membrane has been extensively utilized and investigated for its excellent properties. Herein, we have constructed an active layer (AL) containing cave-like structures utilizing large meniscus interface. Furthermore, the impact of interface structure on the growth process, morphology, and effective surface area of AL has been fully explored with the assistance of sodium dodecyl benzenesulfonate (SDBS).
View Article and Find Full Text PDFReversing Cochlear Nucleus Maladaptive Plasticity via Customized Extracochlear Stimulation: A New Approach for Tinnitus Treatment.
Adv Sci (Weinh)
January 2025
ENT Institute and Department of Otolaryngology, Eye & ENT Hospital of Fudan University, Shanghai, 200031, China.
Tinnitus, a widespread condition affecting numerous individuals worldwide, remains a significant challenge due to limited effective therapeutic interventions. Intriguingly, patients using cochlear implants (CIs) have reported significant relief from tinnitus symptoms, although the underlying mechanisms remain unclear and intracochlear implantation risks cochlear damage and hearing loss. This study demonstrates that targeted intracochlear electrical stimulation (ES) in guinea pigs with noise-induced hearing loss reversed tinnitus-related maladaptive plasticity in the cochlear nucleus (CN), characterized by reduced auditory innervation, increased somatosensory innervation, and diminished inhibitory neural networks.
View Article and Find Full Text PDFChemical reactions with the Casson nanofluid flow by the bioconvective behavior of microorganisms over a spinning disc.
Heliyon
January 2025
Institute of Mathematics, Henan Academy of Sciences, Zhengzhou, 450046, China.
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View Article and Find Full Text PDFfruit extract preadipocyte differentiation inhibition in 3T3-L1 cells.
J Taibah Univ Med Sci
December 2024
Department of Veterinary Pre-Clinical Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Objective: Concerns over the increasing number of obese individuals and the associated health risks have prompted therapeutic option explorations. Similarly, this study aimed to establish fruit extract (SCFE) anti-adipogenic attributes in 3T3-L1 cells.
Methods: The polyphenolic compounds in SCFE were identified with Reverse phase-high performance liquid chromatography (RP-HPLC).
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