The feasibility of developing micro channel artificial lungs is calculated for eight possible strategies: 12 and 25 microm circular channels imbedded in gas-permeable sheets, 12 and 25 microm high open rectangular channels with gas-permeable walls, 12 and 25 microm high broad open channels with support posts and gas-permeable walls, and two 40 microm high screen-filled rectangular channels with gas-permeable walls. Each strategy is considered by imposing a pressure drop maximum of 10 mm Hg and limiting the possibility of shear-induced blood trauma. The pressure drop limit determines the acceptable channel length and required size to oxygenate 4 L/min of venous blood. Circular channels imbedded in open-pore, gas-permeable materials are especially attractive. With 12 microm channels, such a device would require 140 million, 0.8 mm long channels, but the total size of the gas-exchange section would be only 57 ml and a blood prime of only 13 ml. Also attractive are 12 mum high broad open channels with support posts and 40 mum screen-filled rectangular channels. The total size of the former would be 250 ml with a blood prime of 13 ml, and the total size of the latter would be 270 ml with a blood prime of 27 ml.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/MAT.0b013e31817ed9e1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sonochemical synthesis, optical properties and DFT studies on novel (N-arylamino)phenothiazinium dyes suitable for fluorescence cells imaging.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany Janos str., 400028 Cluj-Napoca, Romania. Electronic address:
Novel (N-arylamino)phenothiazinium dyes containing meta-substituted-arylamine auxochrome units were successfully obtained by applying a sonochemical protocol designed for a more efficient energy usage in the preparation of methylene blue (MB) analogues. Single crystal X-ray diffraction analysis revealed the spatial arrangement in aggregated crystalline state of (N-(meta-bromoaryl)amino)phenothiazinium dye with minor variances induced by the nature of the halogenide counterion (iodide or chloride). The optical UV-vis properties of the novel (N-arylamino)phenothiazinium dyes were comparable to those of the parent MB, with the longest wavelength absorption maxima situated in the visible range (640-680 nm), large molar extinction coefficients (log ε = 4.
View Article and Find Full Text PDFEnhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment.
Antioxidants (Basel)
March 2024
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Article Synopsis
- Curcumin, found in turmeric, is recognized for its potential health benefits, including anti-cancer and anti-inflammatory properties, but its absorption in the body may be too low to be effective.
- Dietary sources alone may not provide sufficient curcumin levels, leading researchers to explore methods to enhance its bioavailability, such as using nanoparticles.
- Increasing curcumin levels might boost its health benefits, particularly its antioxidant effects, but it also requires careful monitoring to avoid negative impacts on cellular functions.
Angiotensin I and II Stimulate Cell Invasion of SARS-CoV-2: Potential Mechanism via Inhibition of ACE2 Arm of RAS.
Physiol Res
March 2024
Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovak Republic. and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Angiotensin-converting enzyme 2 (ACE2), one of the key enzymes of the renin-angiotensin system (RAS), plays an important role in SARS-CoV-2 infection by functioning as a virus receptor. Angiotensin peptides Ang I and Ang II, the substrates of ACE2, can modulate the binding of SARS-CoV-2 Spike protein to the ACE2 receptor. In the present work, we found that co incubation of HEK-ACE2 and Vero E6 cells with the SARS-CoV-2 Spike pseudovirus (PVP) resulted in stimulation of the virus entry at low and high micromolar concentrations of Ang I and Ang II, respectively.
View Article and Find Full Text PDFDifferential superoxide production in phosphorylated neuronal nitric oxide synthase mu and alpha variants.
J Inorg Biochem
February 2024
College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address:
Neuronal nitric oxide synthase (nNOS) is regulated by phosphorylation in vivo, yet the underlying biochemical mechanisms remain unclear, primarily due to difficulty in obtaining milligram quantities of phosphorylated nNOS protein; detailed spectroscopic and rapid kinetics investigations require purified protein samples at a concentration in the range of hundreds microM. Moreover, the functional diversity of the nNOS isoform is linked to its splice variants. Also of note is that determination of protein phosphorylation stoichiometry remains as a challenge.
View Article and Find Full Text PDFMiR-15a-5p accelerated vascular smooth muscle cells viabilities and migratory abilities via targeting Bcl-2.
Physiol Res
November 2022
Department of Cardiac Surgery, Xingtai People's Hospital, Xingtai City, Hebei Province, China.
Aortic dissection (AD) caused by the tear in the aortic wall threatens aorta, causing severe chest pain, syncope and even death. Fortunately, development of genetic technology provides promising approaches for AD treatment. To analyze impacts of miR-15a-5p on modulating cell viability and migratory ability of vascular smooth muscle cells (VSMCs).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!