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Development of immune-derived molecular markers for preeclampsia based on multiple machine learning algorithms.
Sci Rep
January 2025
Department of Gynecology and Obstetrics, First Hospital of Jilin University, Changchun, 130031, Jilin, China.
Preeclampsia (PE) is a major pregnancy-specific cardiovascular complication posing latent life-threatening risks to mothers and neonates. The contribution of immune dysregulation to PE is not fully understood, highlighting the need to explore molecular markers and their relationship with immune infiltration to potentially inform therapeutic strategies. We used bioinformatics tools to analyze gene expression data from the Gene Expression Omnibus (GEO) database using the GEOquery package in R.
View Article and Find Full Text PDFCombined Abrocitinib and Acitretin Therapy for Darier's Disease: A Case Report.
Clin Cosmet Investig Dermatol
December 2024
Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong, 510095, People's Republic of China.
Darier's disease (DD) is a rare chronic keratinizing skin disease characterized by dyskeratosis of epidermal cells. We report a case of DD with a medical history spanning over 20 years and recurring symptoms. Pathologically confirmed DD was treated with a combination of abrocitinib and acitretin, resulting in rapid symptom resolution within 2 weeks.
View Article and Find Full Text PDFAntibiotic, hormonal/metabolic, and retinoid therapies for hidradenitis suppurativa.
J Am Acad Dermatol
December 2024
Department of Dermatology, Stanford University School of Medicine, Redwood City, California. Electronic address:
Article Synopsis
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition with unclear causes, making treatment challenging.
- This study reviews the effectiveness and safety of antibiotics, hormonal treatments, and oral retinoids in managing HS.
- Results showed that while antibiotics were effective, hormonal therapies and oral retinoids also showed potential for symptom relief, highlighting the need for customized treatment plans for patients.
Acrodermatitis continua of hallopeau: aggravating factors and treatment outcomes of 96 patients.
J Dermatolog Treat
December 2024
Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Background: Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis variant predominantly affects the distal phalanges of the fingers and toes. However, data on aggravating factors and treatment outcomes is limited.
Objective: This study aims to analyze the aggravating factors and treatment outcomes of ACH in a three-tertiary-hospital in South China.
Update on skin cancer prevention modalities and screening protocols in solid organ transplant recipients: a scoping review.
Arch Dermatol Res
November 2024
Department of Dermatology, Kaiser Permanente, Roseville, CA, USA.
Article Synopsis
- Solid organ transplant recipients (SOTRs) face a significantly higher risk of skin cancer due to long-term use of immunosuppressants, but there are no standardized screening guidelines in the U.S. for this population.
- A scoping review analyzed 36 studies published from 2019 to 2023, focusing on skin cancer risk stratification, screening protocols, and preventive treatments for SOTRs, revealing that most studies emphasize screening and chemoprevention.
- The SUNTRAC tool was identified as a validated model for assessing skin cancer risk, with various preventive strategies suggested, and the review calls for standardized guidelines and more research on patient education and the tool's validation in diverse groups.
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