Vaccines are one of the most powerful immunomodulators and represent perspective direction in the modern strategy of treatment of cancer. Among the gynecological malignancies cervical cancer is the most perspective localization for the implementation of specific therapeutic vaccine, by reason of clear viral ethiopathogenesis and important medical and social effect of the disease. Nowadays, the therapeutic HPV vaccines under research, for precancer and cancer of uterine cervix aimed to eliminate the persistent viral infection. In the review, the results of several clinical trials concerning the effect of HPV vaccines, created on the basis of viral peptides, viral like particles, DNA and viral vectors have been discussed.
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Introduction: Cervical cancer remains the second most common cancer among women worldwide, with 85% of cases occurring in low-and middle-income countries (LMIC). Women living with HIV (WLWH) are at a particularly high risk of developing for high-grade cervical intraepithelial neoplasia (CIN2/3) and cervical cancer, and the standard surgical treatment is far less effective in this population. Thus, research on medical therapies and combination treatment options remain a priority.
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Ecancermedicalscience
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Department of Public Health Dentistry, DY Patil University School of Dentistry, Nerul Navi Mumbai, Sector 7, Nerul, Navi Mumbai 400706, Maharashtra, India.
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