AI Article Synopsis
- The pathways for processing and presenting antigens via MHC class I and II in dendritic cells are well established but regulated by specific signaling, particularly from Toll-like receptors.
- Unique features like cross-presentation occur in dendritic cells and not in other cell types, making their role significant in immune responses.
- Despite this knowledge, the exact processes behind how antigens are trafficked within cells and the role of mechanisms like autophagy in processing remain unclear and need further investigation.
Article Abstract
The principal components of both MHC class I and class II antigen processing and presentation pathways are well known. In dendritic cells, these pathways are tightly regulated by Toll-like-receptor signalling and include features, such as cross-presentation, that are not seen in other cell types. However, the exact mechanisms involved in the subcellular trafficking of antigens remain poorly understood and in some cases are controversial. Recent data suggest that diverse cellular machineries, including autophagy, participate in antigen processing and presentation, although their relative contributions remain to be fully elucidated. Here, we highlight some emerging themes of antigen processing and presentation that we think merit further attention.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735460 | PMC |
| http://dx.doi.org/10.1038/nri2368 | DOI Listing |
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