In Bacillus anthracis, the novel type III pantothenate kinase (PanK(Ba); encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546792 | PMC |
| http://dx.doi.org/10.1128/JB.00860-08 | DOI Listing |
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