The purpose of this study was to investigate the effect of resveratrol, a polyphenol present in grapes and red wine, on ventricular remodeling after myocardial infarction (MI) in rats. After permanent ligation of the left anterior descending artery, surviving rats were randomly allocated to three groups and treated with 1 mg/kg/day resveratrol (R-1 group), 0.1 mg/kg/day resveratrol (R-0.1 group), or vehicles (control group) administered by intraperitoneal injection once daily for four weeks. We examined the effects of resveratrol by echocardiography, hemodynamic studies, histologic examinations, and real-time quantitative polymerase chain reaction. The R-1 group had significantly increased fractional shortening of the left ventricle, ameliorated left ventricular dilatation, reduced left ventricular end-diastolic pressure, and reduced infarct size. In contrast, the R-0.1 group experienced no beneficial effects on myocardial infarction. The R-1 group also had significantly attenuated expression of myocardial atrial natriuretic peptide and transforming growth factor-beta1 mRNAs. This study indicates that resveratrol is a potent cardioprotective agent in MI rats. Its cardioprotective effects may be due to a reduction of atrial natriuretic peptide and transforming growth factor-beta1, which are known to protect the heart from detrimental remodeling.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.lfs.2008.06.016 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dynamic properties of isotropic DMPC/DHPC bicelles: Insights from solution NMR and MD simulations.
Biochem Biophys Res Commun
January 2025
Graduate School of Chemical Sciences and Engineering, Hokkaido University, N13, W8, Sapporo, 060-8628, Japan; Department of Chemistry, Faculty of Science, Hokkaido University, N8, W5, Sapporo, 060-0810, Japan. Electronic address:
Bicelles, an artificial disk-shaped lipid bilayer, are commonly used for the structural and functional characterization of membrane-bound proteins in an environment similar to that in intracellular membranes. Because the dynamics of the lipids that constitute bicelles exert a significant impact on the structure and function of the inserted proteins, we investigated the mobility of lipid molecules in bicelles composed of DMPC (14:0 PC) and DHPC (06:0 PC) using solution NMR and MD calculations. C R relaxation experiments for the acyl groups demonstrated that increasing bicelle sizes limit the rotational diffusion of acyl chain H-C bonds in DMPC.
View Article and Find Full Text PDF3D deuterium metabolic imaging (DMI) of the human liver at 7 T using low-rank and subspace model-based reconstruction.
Magn Reson Med
December 2024
Center for Image Sciences, High Field MR Research Group, Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Purpose: To implement a low-rank and subspace model-based reconstruction for 3D deuterium metabolic imaging (DMI) and compare its performance against Fourier transform-based (FFT) reconstruction in terms of spectral fitting reliability.
Methods: Both reconstruction methods were applied on simulated and experimental DMI data. Numerical simulations were performed to evaluate the effect of increasing acceleration factors.
RHCE genotyping using next generation sequencing: Allele specific reference sequences.
Transfusion
December 2024
School of Biomedical Sciences, Faculty of Health, University of Plymouth, Plymouth, UK.
Background: The Rh blood group system (ISBT004) is encoded by two homologous genes, RHD and RHCE. Polymorphism in these two genes gives rise to 56 antigens, which are highly immunogenic and clinically significant. This study extended previous work on the establishment of RHD allele specific reference sequences using next generation sequencing (NGS) with the Ion Personal Genome Machine (Ion PGM) to sequence the complete RHCE gene.
View Article and Find Full Text PDF[Study on differences in metabolism and transcription of ginseng seeds after morphological post ripening by space flight].
Zhongguo Zhong Yao Za Zhi
September 2024
Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences Changchun 130112, China College of Pharmacy and Biological Engineering, Chengdu University Chengdu 610106, China.
To explore the difference in metabolism and transcription between seeds experiencing space flight and ground seeds after morphological post ripening, this study utilized ginseng seeds experiencing space flight and ground seeds as materials. Metabolomics and transcriptomics analyses were conducted using ultra-high performance liquid chromatography-mass spectrometry(UPLC-MS) and high-throughput transcriptome sequencing(RNA-seq) technologies, so as to identify differential terpenoid metabolites, differential endogenous hormones, and differentially expressed genes. The results showed that through metabolomics analysis, a total of 22 differential terpenoid metabolites were identified in the experimental and control groups, including chikusetsusaponin FK_7, ginsenoside F_2, ginseno-side K, majoroside R_1, ginsenoside Re_5, 12-hydroxyabietic acid, etc; through transcriptomics analysis, 15 differential terpenoid metabolism-related differentially expressed genes were identified in the experimental and control groups, including FCase, AACT, PMK, etc, and these genes were integrated into the pathway based on the MEP and MVA.
View Article and Find Full Text PDFA CIA strategy with eminent drug-loading capacities for tumor ferroptosis-gas synergistic therapy.
Theranostics
December 2024
Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong 510515, China.
: A common challenge of drug loading and delivery using magnetic resonance imaging (MRI) contrast agents (CAs) is the tendency of aggregation and precipitation at high drug loading conditions. Herein, we propose a generic strategy of controlled ideal aggregation (CIA) to restrict the tendency. : Fe, β-Lapachone (LAP), brequinar (BQR), or Sorafenib (SOR) was respectively loaded onto Gd poly (acrylic acid) macrochelate (GP), an MRI CA, in the hollow core of nitrite-modified hollow mesoporous organosilica nanoparticles (HMON-SNO).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!