Chronic L-dopa administration is associated with development of dyskinesias. The molecular mechanisms of these side-effects, however, remain elusive. Dopamine (DA) receptors interact with other receptors to form highly organized complexes where their activity is finely tuned by several proteins. The DA D1R forms a heteromeric complex with the NMDA receptor (NMDAR) and this interaction influences the trafficking of both receptors. Using the 6-hydroxydopamine rat model of Parkinson's disease, we report a correlation between the development of L-dopa-induced dyskinesias and changes in synaptic D1R/NMDAR complexes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.parkreldis.2008.04.022 | DOI Listing |
Publication Analysis
Top Keywords
development l-dopa-induced
8
l-dopa-induced dyskinesias
8
6-hydroxydopamine rat
8
rat model
8
model parkinson's
8
parkinson's disease
8
role receptor
4
receptor heterodimers
4
heterodimers development
4
dyskinesias 6-hydroxydopamine
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!