Effects of N-terminal fragments of beta-endorphin on feeding in chicks.

It is known that N-terminal fragments of beta-endorphin have biological activities, such as an antagonism effect of beta-endorphin (1-31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of beta-endorphin (1-27) (0.4nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. beta-Endorphin (1-17) (2.0nmol) also increased food intake at 30min postinjection. Co-injection of either beta-endorphin (1-27) or (1-17) was effective in reducing full-length beta-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of beta-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.