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ACTB::ZMIZ2-rearranged adnexal carcinoma: a second case.
Virchows Arch
January 2025
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, 37044, Tours, France.
A case of cutaneous adnexal neoplasm with unusual squamoid morphology and harboring an in frame ACTB::ZMIZ2 fusion transcript was recently described. Herein, we report a second case of adnexal carcinoma harboring similar morphology and an identical in frame ACTB::ZMIZ2 fusion transcript. This 2.
View Article and Find Full Text PDFPolyomaviruses and the risk of oral cancer: a systematic review and meta-analysis.
BMC Oral Health
December 2024
Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Objectives: Oral cancer (OC) is the most common malignant tumor of the head and neck (HN) and ranks 16th among the most frequently diagnosed cancers worldwide. A systematic review and meta-analysis aimed to provide an evidence-based analysis of the relationship between polyomaviruses and oral cancer.
Methods: The global online databases was used to identify relevant studies published between January 2000 and September 2024.
Antigen-Specific T Cell Receptor Discovery for Treating Progressive Multifocal Leukoencephalopathy.
bioRxiv
November 2024
Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA.
Background: Progressive multifocal leukoencephalopathy (PML) is a frequently fatal disease of the central nervous system caused by JC virus (JCV). Survival is dependent on early diagnosis and ability to re-establish anti-viral T cell immunity. Adoptive transfer of polyomavirus-specific T cells has shown promise; however, there are no readily available HLA-matched anti-viral T cells to facilitate rapid treatment.
View Article and Find Full Text PDFMunicipal secondary-treated effluent data seem to be a suitable source of information for human viral trends.
Ecotoxicol Environ Saf
December 2024
Chemical Engineering and Renewable Resources for Sustainability (CERES), Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Santa Comba, Portugal. Electronic address:
Article Synopsis
- The study investigates the impact of SARS-CoV-2 on the presence and behavior of JC Virus and Norovirus in municipal wastewater, using samples collected in 2020.
- It finds that JC Virus is consistently present in wastewater, indicating transmission through urine, while Norovirus shows changes with different detection rates before and after SARS-CoV-2 appeared.
- The results highlight the inefficiency of the wastewater treatment plant in removing viruses, which raises concerns about tracking viral disease outbreaks based on effluent data.
Recurrent GRHL fusions in a subset of sebaceoma: microscopic and molecular characterisation of eight cases.
Histopathology
November 2024
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France.
Aims: Sebaceous neoplasms constitute a group of adnexal tumours, including sebaceous adenoma, sebaceoma and sebaceous carcinoma. Although mismatch repair deficiency may be observed, the nature of the genetic alterations contributing to the development of most of these tumours is still unknown. In the present study, we describe the clinical, microscopic, and molecular features of eight sebaceomas with GRHL gene rearrangement.
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