AI Article Synopsis
- * Involving 43 patients, researchers measured the expression levels of key genes using advanced techniques like laser-captured microdissection and real-time PCR.
- * The findings showed significant correlations in mRNA expression between primary tumors and liver metastases, suggesting that these gene expressions could help predict how effective 5FU treatment will be for liver metastases.
Article Abstract
Unlabelled: The aim of this study was to investigate the correlation of the mRNA expressions of 5-fluorouracil (5FU)-related genes in the primary sites and liver metastases of colorectal carcinomas.
Patients And Methods: Patients with liver metastases from colorectal carcinomas were included (n = 43). The expression ratios to beta-actin of mRNA of thymidine synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and oroteta phosphoribosyl transferase (OPRT) were measured in primary and liver metastases of colorectal carcinomas by laser-captured microdissection and real time PCR.
Results: The ratios for the expression of TS, DPD, TP and OPRT mRNAs were significantly correlated between paired primary sites and liver metastases. The mRNA expression ratios of DPD and TP showed a significant correlation both in primary sites and in liver metastases.
Conclusion: Enzymes of the primary colorectal carcinomas can be used in predicting the therapeutic efficacy of 5FU against liver metastases.
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