AI Article Synopsis
- iSPOT is a web tool designed to predict protein-protein interactions using peptide recognition modules, which can help interpret genomic data.
- The tool specifically targets SH3 and PDZ protein domain families and utilizes a database of residue-residue interaction frequencies to score potential interactions.
- It offers functionality to evaluate interaction likelihood, search for potential protein partners in the SWISS-PROT database, and access comprehensive domain/target peptide interaction data.
Article Abstract
Methods that aim at predicting interaction partners are very likely to play an important role in the interpretation of genomic information. iSPOT (iSpecificity Prediction Of Target) is a web tool (accessible at http://cbm.bio.uniroma2.it/iSPOT) developed for the prediction of protein-protein interaction mediated by families of peptide recognition modules. iSPOT accesses a database of position specific residue-residue interaction frequencies for members of the SH3 and PDZ protein domain families. The software utilises this database to provide a score for any potential domain peptide interaction.ISPOT: 1. evaluates the likelihood of the interaction between any of the peptides contained in an input protein and a list of domains of the two different families; 2. searches in the SWISS-PROT database for potential partners of a query domain; and 3. has access to a repository of all the domain/target peptide interaction data.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448410 | PMC |
| http://dx.doi.org/10.1002/cfg.104 | DOI Listing |
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