We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the bla(TEM-1) allele from the bacterial population when it was passaged through ceftazidime or the bla(TEM-12) allele when cultures were passaged through ampicillin.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533445 | PMC |
| http://dx.doi.org/10.1128/AAC.00501-08 | DOI Listing |
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