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| http://dx.doi.org/10.7861/clinmedicine.8-3-338 | DOI Listing |
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Introducing the Index of Response to Stimulation (IRES): A Novel Metric for Assessing Vagus Nerve Stimulation Outcomes in Drug-Resistant Epilepsy.
Medicina (Kaunas)
January 2025
Department of Neurosurgery, University of Medicine and Pharmacy "Carol Davila", 030147 Bucharest, Romania.
: The Index of Response to Stimulation (IRES) is a new index that we introduce in this study to grade the effectiveness of vagus nerve stimulation in the treatment of drug-resistant epilepsy. We assessed 76 patients at 6, 12, and 18 months after VNS evaluating improvement with the IRES in four key dimensions: seizure duration decrease, seizure intensity decrease, improvement in quality of life, and seizure frequency decrease. This scale goes from 0, meaning no improvement, to 8, meaning maximal improvement, making the scale a really good measure of clinical utility.
View Article and Find Full Text PDFTargeting Kv7 Potassium Channels for Epilepsy.
CNS Drugs
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Division of Pharmacology, Department of Neuroscience, University of Naples "Federico II", Naples, Italy.
Voltage-gated Kv7 potassium channels, particularly Kv7.2 and Kv.7.
View Article and Find Full Text PDFA non-inferiority randomized controlled study of Perampanel versus Oxcarbazepine monotherapy for post-stroke epilepsy.
Seizure
January 2025
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China; Institute of Epilepsy, Shandong University, Jinan, Shandong, PR China. Electronic address:
Background: Post-stroke epilepsy (PSE) poses a significant challenge despite advances in stroke treatment. This study compares the efficacy of the novel anti-seizure medication (ASM) Perampanel with the classical ASM Oxcarbazepine in treating PSE.
Methods: This prospective randomized controlled trial recruited PSE patients from September 2022 to January 2024 across multiple hospitals.
Hexamodal awake brain mapping (language, sensorimotor, ictal, visual, auditory) for multilobar resection in a dominant hemisphere parieto-fronto-temporo-occipital cortical malformation with drug-resistant epilepsy.
Neurosurg Focus Video
January 2025
Department of Neurosurgery.
Surgically remediable epilepsy of the eloquent brain poses the added challenge of preserving function while curing disease. Long-standing epileptogenic lesions have tenacious seizure networks and significant functional reorganizations. Large multilobar lesions may involve multiple functional areas, thereby challenging the limits of functional brain mapping.
View Article and Find Full Text PDFFirst clinical post-approval, observational study to assess clinical safety and effectiveness of brivaracetam sustained-release formulation in real-life settings of India: BEAM study.
Seizure
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Medical Affairs, Torrent Pharmaceuticals Limited, Ahmedabad, Gujarat, India.
Purpose: Brivaracetam (BRV) sustained-release (SR) tablets have recently been approved to treat focal seizures in India. SR formulations enhance patient adherence and quality of life (QoL). We assessed safety and effectiveness of BRV-SR for epilepsy management in Indian real-life settings.
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