Background And Purpose: There have been few reports regarding the proximally based sural artery flap, which is useful for reconstruction of soft tissue defects around the knee and on the proximal third and middle third of the lower leg. Here we report our experience with 10 patients.
Patients: The defects in our 10 cases were around the knee (4), on the proximal third of the lower leg (4), and on the middle third (2). 8 patients had fasciocutaneous flaps and 2 had adipofascial flaps. The flap size ranged from 4 to 10 cm in length, and from 5 to 8 cm in width. The pedicle length ranged from 12 to 20 cm.
Results: All 10 flaps survived. Congestion and tip necrosis occurred in 1 case with a fasciocutaneous flap, which healed without complications. A superficial infection occurred in 1 case with a fasciocutaneous flap, which healed with antibiotic treatment. Necrosis of grafted skin occurred in 2 cases of adipofascial flap; only one of them, however, required additional surgery. No morbidity of the donor site and no functional deficits were detected in any of the 10 cases.
Interpretation: The proximally based sural artery flap is useful for reconstruction of soft tissue defects around the knee joint and on the proximal third and middle third of the lower leg. It is a relatively easy and reliable procedure.
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http://dx.doi.org/10.1080/17453670710015274 | DOI Listing |
JAMA
January 2025
Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Importance: The impact of adjunctive intra-arterial tenecteplase administration following near-complete to complete reperfusion by endovascular thrombectomy (EVT) for acute ischemic stroke is unknown.
Objective: To assess the efficacy and adverse events of adjunctive intra-arterial tenecteplase in patients with large vessel occlusion stroke who had achieved near-complete to complete reperfusion (defined as a score on the expanded Thrombolysis in Cerebral Infarction [eTICI] scale of 2c to 3) after EVT.
Design, Setting, And Participants: Investigator-initiated, randomized, open-label, blinded outcome assessment trial implemented at 34 hospitals in China among 540 patients with stroke due to proximal intracranial large vessel occlusion within 24 hours of the time they were last known to be well, with an eTICI score of 2c to 3 after EVT, and without prior intravenous thrombolysis.
JAMA
January 2025
Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Importance: Persisting or new thrombi in the distal arteries and the microcirculation have been reported to limit the benefits of successful endovascular thrombectomy for patients with acute ischemic stroke. It remains uncertain whether intra-arterial thrombolysis by urokinase following near-complete to complete reperfusion by thrombectomy improves outcomes among patients with ischemic stroke due to large vessel occlusion.
Objective: To assess the efficacy and adverse events of intra-arterial urokinase after near-complete to complete reperfusion by thrombectomy for acute ischemic stroke due to large vessel occlusion.
Arch Dermatol Res
January 2025
Department of Dermatology, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye.
Introduction: Psoriasis is a chronic inflammatory skin disorder affecting millions worldwide. Dermoscopy and proximal nailfold capillaroscopy have emerged as valuable tools for understanding the pathophysiology and treatment response of psoriasis lesions.
Objectives: This study aimed to contribute to the limited literature on using dermoscopic findings to detect treatment effectiveness in patients with psoriasis vulgaris.
Mikrochim Acta
January 2025
College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
An innovative colorimetric sensing strategy was developed for the detection of glucose by the integration of glucose aptamer, glucose oxidase (GOx), and horseradish peroxidase (HRP), termed aptamer proximal enzyme cascade reactions (APECR). In the presence of glucose, aptamer binding enables GOx to catalyze glucose oxidation into HO efficiently. Subsequently, the adjacent HRP catalyzes the oxidation of the peroxidase substrate, 2,2'-biazobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), utilizing the generated HO, resulting in a distinct color change.
View Article and Find Full Text PDFSpine J
January 2025
Orthopedic Department, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, 49 North Garden Road, Haidian District, Beijing 100191, China; Beijing Key Laboratory of Spinal Disease Research, 49 North Garden Road, Haidian District, Beijing 100191, China. Electronic address:
Background Context: Osteoporotic vertebral compression fracture (OVCF) causes pain, kyphosis and neurological damage, which significantly affect patients' quality of life. Patients with OVCF are often elderly and have severe osteoporosis, which makes preoperative symptom more serious, postoperative recovery worse and the incidence of postoperative complications high. The paraspinal muscles have been well studied in adult spinal deformities, but there is no conclusive evidence that their findings can be applied to OVCF.
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