AI Article Synopsis
- Metanephric adenoma is a benign kidney tumor that resembles malignant tumors like papillary RCC and Wilms' tumor.
- Methods to differentiate these tumors include advanced techniques that may not always be available.
- The study found that S100 protein was strongly expressed in metanephric adenoma, weakly in some Wilms' tumors, and not at all in papillary RCC, suggesting S100 as a helpful diagnostic tool for metanephric adenoma.
Article Abstract
Metanephric adenoma is a benign renal neoplasm with morphologic features similar to those of malignant renal neoplasms, such as papillary renal cell carcinoma (RCC) and Wilms' tumor. Different methods have been used to distinguish between metanephric adenoma and papillary RCC and Wilms' tumor. However, some techniques are not always available, such as certain immunohistochemical stains, cytogenetics, molecular genetics, and electron microscopy. In the current study, we compared the expression of S100 protein in 15 cases of metanephric adenoma, 10 cases of Wilms' tumor, and 13 cases of papillary RCC. Our results revealed strong expression of S100 proteins in all cases of metanephric adenoma, weak expression in two cases of Wilms' tumor, and no expression in any of the cases of papillary RCC. These findings indicate that S100 could be a useful and accessible tool for the diagnosis of metanephric adenoma.
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| http://dx.doi.org/10.1016/j.prp.2008.04.013 | DOI Listing |
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