AI Article Synopsis
- Successful antibiotics work by inhibiting bacterial growth through complex mechanisms that target multiple sites rather than just a single enzyme.
- These antibiotics often target several genes, which helps slow down the bacteria's ability to develop resistance.
- The text discusses new and recently approved antibiotics using the concept of "antibacterial polypharmacology," emphasizing the benefits of targeting multiple pathways.
Article Abstract
All antibiotics that have been successfully employed for decades as monotherapeutics in the treatment of bacterial infections rely on mechanisms of bacterial growth inhibition which are by far more complex than inhibition of a single enzyme. Such successful antibiotics have in common that they address several targets in parallel and/or that their targets are encoded by multiple genes. Such multiplicity of targets and of target genes has the advantage that the emergence of spontaneous target-related resistance is a comparatively slow process. Recently registered antibiotics and novel antibiotics in development are discussed in the light of this promising concept of antibacterial polypharmacology.
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| http://dx.doi.org/10.1016/j.coph.2008.06.008 | DOI Listing |
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