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| http://dx.doi.org/10.1093/nar/19.14.4008 | DOI Listing |
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Comparative efficacy of essential oils against Cutibacterium acnes: Effect upon strains from phylotypes with different virulence patterns.
Microb Pathog
February 2025
Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal; Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal; Labfit-Health Products Research and Development Lda, UBImedical, Estrada Nacional 506, 6200-284, Covilhã, Portugal. Electronic address:
Objectives: Despite being a commensal of human skin, Cutibacterium acnes plays an important role in the pathogenesis of Acne vulgaris, with the loss of bacterial phylotype diversity being related to disease progression. This study evaluated differences in the virulence profile of C. acnes strains from different phylotypes and investigated the possible phylotype-selective efficacy of essential oils (EOs) from Thymus x citriodorus (TC), Thymus mastichina, and Cistus ladanifer compared to Melaleuca alternifolia (tea tree), focusing on both planktonic and biofilm growth forms, the latter being related with pathogenesis and treatment resistance.
View Article and Find Full Text PDFIdentification of a novel SNP mutation causing drop-out alleles in a paternity test using combined nest and touch-down PCR with Sanger sequencing.
Ann Hum Biol
February 2024
Department of Human Anatomy, School of Basic Medicine, Shenyang Medical College, Shenyang, P.R. China.
Background: Short tandem repeat (STR) markers are widely used in forensic DNA analysis due to their ability to provide automated and standardised typing. However, incorrect STR typing can have a significant impact on forensic outcomes.
Aim: In this study, we detected drop-out alleles at the SE33 locus in a putative father-son pair using the Microreader 28 A ID System.
Loss in Pluripotency Markers in Mesenchymal Stem Cells upon Infection with .
J Microbiol Biotechnol
December 2024
Microbiology and Immunology Department, Faculty of Medicine, Mutah University, Al-Karak, Jordan.
The intracellular pathogen can inflict substantial damage on the host. Notably, Chlamydia infection is acknowledged for its precise modulation of diverse host signaling pathways to ensure cell survival, a phenomenon intricately connected to genetic regulatory changes in host cells. To monitor shifts in gene regulation within Chlamydia-infected cells, we employed mesenchymal stem cells (MSCs) as a naïve, primary cell model.
View Article and Find Full Text PDFPreliminary study of molecular identification of Mycobacterium bovis from cow's milk in Lorestan (Iran).
Sci Rep
October 2024
Department of pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
Bovine tuberculosis is one of the most important common infectious diseases between humans and livestock. Cow's milk can be investigated as one of the transmission reservoirs of the disease. Our study was conducted to investigate the presence of Mycobacterium bovis (M.
View Article and Find Full Text PDFDetection Of CCR5 Delta-32 Mutation Using High-Resolution Melting Curve Analysis: Challenges and Facts.
Curr HIV Res
January 2025
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The CCR5 gene is crucial for HIV infection resistance, particularly where the delta-32 mutation is present, making studying this mutation important for understanding HIV resistance.
- The research aimed to create a High-Resolution Melting (HRM) assay to detect delta-32 mutations in DNA, considering various factors that affect the melting temperature (Tm) differentiation but encountered challenges in achieving expected results.
- Despite some samples showing heterozygote mutations, the study concluded that accurately detecting the delta-32 mutation with the HRM assay is complex and necessitates specific experimental conditions, contrary to previous literature.
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