Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1).

Bioorg Med Chem Lett

Bristol-Myers Squibb Pharmaceutical Research and Development, Princeton, NJ 08543, USA.

Published: August 2008

This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1.

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http://dx.doi.org/10.1016/j.bmcl.2008.06.026DOI Listing

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