Objective: To study the protective effects of Isodon lophanthoides (ILVG) aqueous extract on acute hepatic injury induced by D-galactosamine (D-Gal) in rats.
Methods: 60 rats were divided into control group, model group, and low, middle, high dosage group, Bifendate group randomly. In test groups, rats received either ILVG aqueous extract (15, 7.5, 3.75 g/kg) or Bifendate (45 mg/kg) by gastric perfusion daily for 7 consecutive days. On the sixth day, D-Gal (550 mg/kg) was given to rats by oral administration. The levels of ALT, AST, ALP, TBA, T-Bil, TP and ALB in serum were analyzed. The weight of body, liver, spleen and thymus of each rat were measured. The hepatic glycogen content was analyzed individually. Liver tissue pathology was observed.
Results: ILVG coud decrease the ALT, AST, ALP, TBA and T-Bil in serum, increase TP, ALB and hepatic glycogen content and restrain the enlargement of liver and the shrinkage of thymus, reduce necrosis in pathological observation.
Conclusion: ILVG aqueous extract possesses the effect on protecting on acute hepatic injury induced by D-Gal in rats, its effect is related to multifarious mechanism.
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