Objective: To study the constituents isolated from Juncus effuses Linn..
Methods: The compounds were isolated through chromatographic approaches, such as Silica gel. CC, Sephadex LH-20 and were identified by a combination of spectroscopic methods (UV, MS, 1H-NMR, 13C-NMR and NOE).
Results: 8 kinds of compounds were identified which included four flavonoids, luteolin (I), eriodictyol (II), 2', 5', 5, 7-tetrahydroxyflavone (III), glucoluteolin (IV); two aromatic compounds, methyl p-hydroxybenzoate (V), vanillic acid (VI); a fatty acid, hexadecanoic acid (I) and an alkane, n-Tetradecane (VIII).
Conclusion: Compound II, III, V, VI, VII, VIII were firstly isolated from this plant.
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J Geriatr Cardiol
November 2024
Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
Background: Human interleukin (IL)-37 is a constituent of the IL-1 family with potent anti-inflammatory and immunosuppressive attributes. It has been demonstrated extensive beneficial effects on various diseases; however, its role in the pathogenesis of diabetic cardiomyopathy (DCM) remains unclear.
Methods: , DCM mouse model was established with streptozotocin injection and a high-fat diet in WT and cardiac fibroblasts (CFs) specific hIL-37b overexpression mice (IL-37-Tg).
J Org Chem
December 2024
Department of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Nine new structurally diverse filicinic acid-based meroterpenoids (-) with four kinds of carbon skeletons were isolated from the rhizomes of . Their structures, including the absolute configurations, were elucidated by comprehensive analysis of spectroscopic data, quantum chemical calculations, and single-crystal X-ray diffraction. Structurally, compounds - feature an unprecedented 6/6/5/6/6/6 hexacyclic system with a rare oxaspiro[4.
View Article and Find Full Text PDFMar Drugs
December 2024
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
To optimize the utilization of the sea star , which has demonstrated potential pharmaceutical properties in Chinese folk medicine, ten glycosides of polyhydroxy steroids, pectiniferosides A-J (-), were isolated and characterized. These compounds possess 3β, 6α, 8, 15α (or β), 16β-pentahydroxycholestane aglycones with sulfated and (or) methylated monosaccharides. The chemical structures of - were determined using NMR spectroscopy and HR-ESI-MS.
View Article and Find Full Text PDFChem Biodivers
December 2024
University of Jinan, School of Biological Science and Technology, 336 West Road of Nanxinzhuang, 250022, Jinan, CHINA.
Four unreported pyridine alkaloids, curviflorines A-D (1-4), two undescribed iridoids, curviridoids A and B (5 & 6), and one known iridoid glycoside (7), were isolated from the twigs and leaves of Phlogacanthus curviflorus. The structures of these compounds were established by detailed interpretation of MS and NMR data, with the absolute configurations being assigned via comparison of experimental and calculated electronic circular dichroism spectra. Notably, it is the first report of alkaloidal constituents (1-4) from the genus Phlogacanthus.
View Article and Find Full Text PDFFront Microbiol
December 2024
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
This study aimed to screen native methionine gamma-lyase (L-methioninase) producing bacteria from soil samples and optimize the culture media for enhanced enzyme production using statistical design. Three bacteria, were identified as novel L-methioninase producers, which alternative source of L-methioninase for cancer treatment could be utilized alongside other therapeutic agents. The bacteria were isolated from various garden soils and cultured on a modified M9 medium and screened by Nessler reagent.
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