A variety of lipophilic 2-oxoamides containing sulfonamide analogs of gamma-amino acids as well as acyl sulfonamides of gamma-aminobutyric acid were synthesized. Their ability to inhibit intracellular GIVA cPLA2 and GVIA iPLA2 as well as secreted GV sPLA2 was evaluated. The sulfonamide group seems a bioisosteric group suitable to replace the carboxyl group in 2-oxoamide inhibitors of GVIA cPLA2.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678953 | PMC |
| http://dx.doi.org/10.1002/psc.1048 | DOI Listing |
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