Using a one-megabase BAC-based array comparative genomic hybridization technique (aCGH), we have investigated a series of 16 low-grade gliomas (LGGs) and their subsequent progression to higher-grade malignancies. The most frequent chromosome imbalances in primary tumors were gains of chromosomes 7q, 8q, and 22q, and losses of chromosomes 1p, 13q, and 19q. In tumor progression, gains of chromosomes 11q, 7q, 20q, and 21q, and losses of chromosomes 9p, including CDKN2A locus, 19q, 14q, 1p, and 6q were the most frequent genomic disequilibria. Progressive tumors were more imbalanced than primary tumors in terms of altered chromosomal arms (3.8 vs. 6.6 in mean abnormal chromosomal arm) and altered BACs (17 vs. 21%). Interestingly, putative novel candidate genes associated with glioma progression were identified, in particular DOCK8, PTPRD, CER1, TPHO, DHFR, MSH3, ETS1, ACACA, and CSE1L.
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http://dx.doi.org/10.1007/s11060-008-9644-z | DOI Listing |
Front Oncol
December 2024
Division of Critical Care and Pulmonary Medicine, Department of Pediatrics, St Jude Children's Research Hospital, Memphis, TN, United States.
Introduction: Central nervous system (CNS) tumors are the second most prevalent malignant neoplasms in childhood, with surgical resection as the primary therapeutic approach. The immediate postoperative period following CNS tumor resection requires intensive care to mitigate complications associated with high morbidity and mortality.
Objective: The primary aim of this study is to comprehensively describe the postoperative complications observed in pediatric patients who underwent primary CNS tumor resection and were subsequently admitted to the pediatric intensive care unit (PICU) at Hospital Universitario Fundación Valle del Lili in Colombia.
Lancet Oncol
December 2024
Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:
Background: Gliomas are a major cause of cancer-related death among children, adolescents, and young adults (age 0-40 years). Primary mismatch repair deficiency (MMRD) is a pan-cancer mechanism with unique biology and therapeutic opportunities. We aimed to determine the extent and impact of primary MMRD in gliomas among children, adolescents, and young adults.
View Article and Find Full Text PDFComput Biol Med
December 2024
Department of Computer Science, University of Toronto, 40 St George St., Toronto, M5S 2E4, ON, Canada; Neurosciences & Mental Health Research Program, The Hospital for Sick Children, 686 Bay St., Toronto, M5G 0A4, ON, Canada; Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, 170 Elizabeth St., Toronto, M5G 1H3, ON, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada; Department of Medical Imaging, University of Toronto, 263 McCaul St., Toronto, M5T 1W7, ON, Canada; Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, M5S 3G8, ON, Canada. Electronic address:
Medical image analysis has significantly benefited from advancements in deep learning, particularly in the application of Generative Adversarial Networks (GANs) for generating realistic and diverse images that can augment training datasets. The common GAN-based approach is to generate entire image volumes, rather than the region of interest (ROI). Research on deep learning-based brain tumor classification using MRI has shown that it is easier to classify the tumor ROIs compared to the entire image volumes.
View Article and Find Full Text PDFBackground: Due to their anatomical locations, optic pathway gliomas (OPGs) can rarely be cured by resection. Given the importance of preserving visual function, we analyzed radiological and visual acuity (VA) outcomes for the type II RAF inhibitor tovorafenib in the OPG subgroup of the phase 2 FIREFLY-1 trial.
Methods: FIREFLY-1 investigated the efficacy (arm 1, n=77), safety, and tolerability (arms 1/2) of tovorafenib (420 mg/m2 once weekly; 600 mg maximum) in patients with BRAF-altered relapsed/refractory pediatric low-grade glioma (pLGG).
Quant Imaging Med Surg
December 2024
Department of Radiology, the 8th Medical Center of PLA General Hospital, Beijing, China.
Background: Two post-processing methods of dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI), arterial input function (AIF) and gamma-variate fitting (GVF), can both derive cerebral blood flow (CBF). Moreover, AIF can provide T2* and T1 leakage indicators. This study aimed to compare the consistency of normalized CBF between different post-processing methods of DSC-PWI and arterial spin labeling (ASL) in gliomas, and take the quantitative metrics percentage of signal recovery (PSR) as a reference to verify the value of T2* and T1 leakage indicators in characterizing leakage effect and evaluating the grading of gliomas.
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