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| http://dx.doi.org/10.4088/pcc.v10n0312a | DOI Listing |
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α2δ-2 regulates synaptic GluK1 kainate receptors in Purkinje cells and motor coordination.
Brain
October 2024
Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Article Synopsis
- - Gabapentin and pregabalin, drugs used for neuropathic pain and epilepsy, interact with α2δ-2 proteins in the brain, which can lead to movement disorders, but the exact mechanisms are unclear.
- - Research showed that α2δ-2 enhances the activity of GluK1 receptors, but pregabalin reduces this enhancement, indicating a complex relationship between these proteins.
- - The study also found that blocking GluK1 receptors affected synaptic signals in Purkinje cells, and altering the interaction between α2δ-2 and GluK1 impacted overall receptor activity, suggesting potential pathways for managing drug side effects.
Neuropharmacology of Neuropathic Pain: A Systematic Review.
Cureus
September 2024
Cardiology/Global Clinical Scholars Research Training, Harvard Medical School, Boston, USA.
Article Synopsis
- * A review of various studies found that gabapentinoids (like gabapentin and pregabalin) and tricyclic antidepressants (like amitriptyline) are effective for managing neuropathic pain by targeting neurotransmitters.
- * While selective serotonin reuptake inhibitors (SSRIs) are less effective for this type of pain, cannabinoids showed promise with mild side effects; opioids are generally a last resort due to their risks.
Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline.
J Clin Sleep Med
September 2024
Department of Neurology, Vanderbilt University, Nashville, TN.
Introduction: This guideline establishes clinical practice recommendations for Treatment of Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder (PLMD) in adults and pediatric patients.
Methods: The American Academy of Sleep Medicine (AASM) commissioned a task force of experts in sleep medicine to develop recommendations and assign strengths based on a systematic review of the literature and an assessment of the evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. The task force provided a summary of the relevant literature and the certainty of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations that support the recommendations.
Restless legs syndrome. Pathophysiology, diagnosis and treatment.
Med Clin (Barc)
August 2024
Servicio de Neurología, Hospital Universitario San Pedro, Logroño, La Rioja, España.
Restless legs syndrome is the most prevalent sleep-related movement disorder, affecting 5-10% of the population, characterized by an urge to move that appears during rest or is exacerbated by rest, primarily in the lower extremities, that occurs in the evening or night and that disappears during movement or is improved by movement. Restless legs syndrome significantly impacts sleep, mood, and quality of life. Its pathophysiology involves a complex interplay of genetic and environmental factors, as well as comorbidities, leading to alterations in brain iron resulting in dysfunction in dopaminergic, adenosine, and glutamatergic pathways.
View Article and Find Full Text PDFManaging Opioid Withdrawal Symptoms During the Fentanyl Crisis: A Review.
Subst Abuse Rehabil
April 2024
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Illicitly manufactured fentanyl (IMF) is a significant contributor to the increasing rates of overdose-related deaths. Its high potency and lipophilicity can complicate opioid withdrawal syndromes (OWS) and the subsequent management of opioid use disorder (OUD). This scoping review aimed to collate the current OWS management of study populations seeking treatment for OWS and/or OUD directly from an unregulated opioid supply, such as IMF.
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