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Anti-HIV evaluation of benzo[d]isothiazole hydrazones. | LitMetric

Anti-HIV evaluation of benzo[d]isothiazole hydrazones.

Eur J Med Chem

Dipartimento Farmaceutico, Università degli Studi di Parma, Via G.P. Usberti 27/A, Parma 43100, Italy.

Published: April 2009

AI Article Synopsis

Article Abstract

The synthesis and the anti-HIV-1 activity of novel benzo[d]isothiazole hydrazones are reported. Target compounds tested in MT-4 cells cultures for their anti-HIV properties against wild type HIV-1 and HIV strains carrying clinically relevant mutations (EFV(R), Y181C and K103/Y181C) showed good activity against wild type HIV-1 and against the EFV(R) mutant. In terms of SAR the relevant result was that, in the class of benzisothiazole hydrazones, the benzo[d]isothiazol-3(2H)-one moiety (compounds 1 and 4) is an essential structural requirement for the antiretroviral activity.

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Source
http://dx.doi.org/10.1016/j.ejmech.2008.05.030DOI Listing

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