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Langerhans cells orchestrate apoptosis of DNA-damaged keratinocytes upon high-dose UVB skin exposure.
Eur J Immunol
December 2024
Department of Dermatology, Venereology & Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Article Synopsis
- UV irradiation can lead to mutations that increase the risk of skin cancers, such as melanoma, with high doses causing inflammation and acute sunburn characterized by cell death.
- This study focused on Langerhans cells (LC) in the skin, investigating their role in the immune response following intense UVB exposure in mice.
- Findings revealed that LC activation was linked to increased inflammation and programmed cell death in damaged skin cells, highlighting their importance in managing UV-induced skin damage and potential cancer risk.
Aortic Pseudoaneurysm-Related Acute Ortner's Syndrome Presenting as Sudden Hoarseness: A Case Series.
Am J Case Rep
August 2024
Department of Cardiology, Cardiovascular Institute, Hospital Clínico San Carlos, Madrid, Spain.
Article Synopsis
- Two case studies of men aged 76 and 60 presented with sudden hoarseness due to aortic arch pseudoaneurysm, confirmed by laryngoscopy and CT scans, leading to treatment through endovascular aortic repair.
- Despite treatment, one patient faced persistent hoarseness and the other developed severe complications resulting in death, emphasizing the need for immediate diagnosis of hoarseness that could signal aortic-related issues.
SARS-CoV-2 immunity and reasons for non-vaccination among healthcare workers from eastern and northern Switzerland: results from a nested multicentre cross-sectional study.
Swiss Med Wkly
April 2024
Cantonal Hospital St Gallen, Division of Infectious Diseases and Hospital Epidemiology, St Gallen, Switzerland.
Aims Of The Study: We aimed to assess the extent of SARS-CoV-2 humoral immunity elicited by previous infections and/or vaccination among healthcare workers, and to identify reasons why healthcare workers decided against vaccination.
Methods: This nested cross-sectional study included volunteer healthcare workers from 14 healthcare institutions in German-speaking Switzerland. In January 2021, SARS-CoV-2 vaccines were available for healthcare workers.
Epstein-Barr virus reactivation is not causative for post-COVID-19-syndrome in individuals with asymptomatic or mild SARS-CoV-2 disease course.
BMC Infect Dis
November 2023
Department of Transfusion Medicine, University Hospital of Salzburg (SALK), Paracelsus Medical University (PMU) Salzburg, Müllner-Hauptstraße 48, Salzburg, 5020, Austria.
Purpose: Post-COVID-19-Syndrome (PCS) frequently occurs after an infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, the understanding of causative mechanisms is still limited. Aim of this study was to determine the PCS rate among SARS-CoV-2 seropositive blood donors as representatives of supposedly healthy adults, who had experienced an asymptomatic or mild COVID-19 disease course, and to examine whether Epstein-Barr virus (EBV) is reactivated in individuals reporting PCS.
View Article and Find Full Text PDFAcute-onset dysphonia secondary to a ruptured mycotic aortic arch aneurysm: a rare case of Ortner syndrome.
Intern Med J
October 2023
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
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