AI Article Synopsis
- The paper reviews how carboxylic acids interact with carbodiimides in chemical reactions.
- It introduces the concept of an "introverted" carboxylic acid, which uses a unique structure to trap reactive intermediates during these reactions.
- The reaction between this introverted acid and diisopropyl carbodiimide can lead to the formation of either O-acylisourea or N-acylurea, depending on the conditions.
Article Abstract
The reaction of carboxylic acids with carbodiimides is reviewed, and an "introverted" carboxylic acid is proposed as a means of trapping reactive intermediates along the reaction pathway. The introverted acid is a cavitand with the carboxylic function directed toward the floor of the cavity. Its reaction with diisopropyl carboodiimide gives a covalent adduct that is either the elusive O-acylisourea or the commonly encountered N-acylurea.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2031843 | PMC |
| http://dx.doi.org/10.1016/j.tet.2007.03.075 | DOI Listing |
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