Osteoblastomas are rare bone-producing neoplasms that generally occur in the young and can be misdiagnosed as an osteosarcoma if correlation with clinical history, radiology, and histology is not carefully considered or if the several variants of osteoblastoma are not recognized. These variants lie on a morphologic spectrum between conventional osteoblastoma and osteosarcoma. Aggressive osteoblastoma is one such subtype. As the name implies, the histologic features of aggressive osteoblastoma may appear malignant, and its biologic behavior may separate it from conventional osteoblastoma. We report a case of aggressive osteoblastoma occurring in the femoral diaphysis of a 12-year-old girl; this osetoblastoma was dyssynchronous from the radiologic appearance and a diagnostic challenge. Cytogenetic evaluation of the neoplasm revealed a pseudodiploid clone with a balanced translocation involving chromosomes 4, 7, and 14. Using the premise that cytogenetics might be useful as a diagnostic tool for a more specific classification, we reviewed the literature in order to compare our findings with known chromosomal aberrations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/1066896908319675 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Malignant Bone-Forming Neoplasm With NIPBL::BEND2 Fusion.
Genes Chromosomes Cancer
November 2024
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Conventional high-grade osteosarcomas are characterized by aggressive radiologic features, cytologic pleomorphism, and complex genomics. However, rare examples of osteosarcomas remain challenging due to unusual histology, such as sclerosing or osteoblastoma-like features, which may require molecular confirmation of their complex genetic alterations. We have encountered such a case in a 17-year-old man, who presented with a third metatarsal sclerotic bone lesion, found incidentally in the work-up of a foot trauma.
View Article and Find Full Text PDFThoracic aneurysmal bone cyst secondary to osteoblastoma: unique surgical management. Illustrative case.
J Neurosurg Case Lessons
November 2024
Department of Neurosurgery, The University of Texas Medical Branch at Galveston, Texas.
Background: Aneurysmal bone cysts (ABCs) are rare, benign, yet locally aggressive lesions that contain blood-filled channels that rarely occur in the thoracic spine of adults. The literature on the treatment of spinal ABCs is sparse, but the consensus is to achieve gross-total resection (GTR) due to these lesions being locally aggressive and to prevent recurrence.
Observations: This report describes a 35-year-old female admitted with back pain and right T5 dermatome radiculopathy without any inciting events.
A benign tumor of substantial size: Mandibular epithelioid osteoblastoma in a socioeconomically challenged patient.
J Craniomaxillofac Surg
January 2025
Division of Head and Neck Surgery, Department of Oral and Maxillofacial Surgery, University of Florida College of Medicine, Jacksonville, Florida, USA.
Article Synopsis
- Epithelioid osteoblastoma (EOB) is a rare and benign bone tumor marked by atypical osteoblasts in a vascular environment, needing differentiation from aggressive tumors like osteosarcoma.
- A case study highlights a 30-year-old man's large mandibular EOB, causing pain and disfigurement, which was managed through radical surgery and reconstruction.
- This situation underscores the necessity of collaborative healthcare approaches, careful surgical planning, and consideration of socioeconomic factors in patient treatment and recovery.
Aggressive osteoblastoma of the cervical spine and resultant complication due to swollen oxidized regenerated cellulose: A case report.
Surg Neurol Int
January 2024
Department of Neurosurgery, Kocaeli University, School of Medicine, Kocaeli, Turkey.
Background: Osteoblastomas, although rare, are benign primary bone tumors, with cervical spine involvement being exceptionally uncommon. Late diagnosis, especially in aggressive cases, can lead to surgical challenges. Oxidized regenerated cellulose (ORC) used for hemostasis may result in complications if left in the surgical field.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!