The susceptibility patterns to 'classic' tuberculous pleuritis can reflect the circulating strains in a society. The records of patients with 'classic' tuberculous pleuritis were reviewed retrospectively. Eighty-six patients were selected who were hospitalized between January 1990 and April 1994. Pleural fluid and tissue samples of patients were cultured in Lowenstein-Jensen medium. The isolated strains were subjected to drug susceptibility testing based on the absolute concentration method. We obtained 40 positive cultures in 86 patients with 'classic' tuberculous pleuritis. The resistance rate was 75% to one or more drugs, 27.5% to two drugs, 15% to three drugs, and 10% to four drugs. The resistance rates to isoniazid, rifampicin, streptomycin, and ethambutol were 32.5, 55,42.5 and 32.5%, respectively. The resistance to isoniazid + rifampicin was 7.5%. Our findings indicate that the resistance rates for 'classic' tuberculous pleuritis are considerably high, reflecting the currently circulating resistance patterns in our region. The best regimen for new tuberculous cases and the appropriate regimens for drug-resistant cases should be designed and conducted by a nationwide institution.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0924-8579(96)00335-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intrasellar Tuberculosis Presenting as Pituitary Apoplexy: A Case Report.
Cureus
December 2024
Department of Neurosurgery, NMC Royal Hospital, Abu Dhabi, ARE.
Patients presenting with acute onset of headache and ophthalmoplegia are clinically diagnosed as having a pituitary adenoma with apoplexy. Rarely, other diseases can mimic this condition clinically and radiologically, requiring a high index of suspicion to reach the correct diagnosis. We present a case of a 37-year-old male of Indian origin, who had intra- and supra-sellar tuberculosis (TB), presenting with classical clinical features of pituitary apoplexy and constitutional symptoms.
View Article and Find Full Text PDFExploring the Antimycobacterial Potential of Podocarpusflavone A from : In Vitro and In Vivo Insights.
Pharmaceuticals (Basel)
November 2024
Laboratório de Produtos Bioativos (LPBio), Instituto de Ciências Farmacêuticas, Universidade Federal do Rio de Janeiro, Campus Macaé, Macaé 27930-560, RJ, Brazil.
: Tuberculosis (TB) is one of the leading infectious causes of death worldwide, highlighting the importance of identifying new anti-TB agents. In previous research, our team identified antimycobacterial activity in leaf extract; therefore, this study aims to conduct further exploration of its potential. : Classical chromatography was applied for fractionation and spectrometric techniques were utilized for chemical characterization.
View Article and Find Full Text PDFIsolation and Antibiotic Resistance Rates of complex in Mycolor TK System.
Infect Dis Clin Microbiol
December 2024
Department of Medical Pharmacology, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Türkiye.
Objective: Tuberculosis (TB) is a public health problem. This study aimed to determine the growth rates and drug susceptibility levels of patients with complex (MTC) growth in cultures obtained and to compare the results with the growth rates and drug susceptibility levels found in our country and other countries. It also aimed to evaluate the results of supplementing classical methods such as Lowenstein-Jensen (LJ) with liquid TK MEDIUM and to determine the relationship between the growth rates obtained with both methods.
View Article and Find Full Text PDFDeveloping novel indoles as antitubercular agents and simulated annealing-based analysis of their binding with MmpL3.
Future Med Chem
January 2025
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Aim: This research aimed to develop novel indole-2-carboxamides as potential antitubercular agents using rational drug design. It also focused on identifying the critical interactions required for these compounds to exhibit effective antitubercular activity.
Materials And Methods: Novel indole-2-carboxamides targeting MmpL3 were designed based on SAR, synthesized, and tested for their antitubercular and induction properties.
Collet-Sicard Syndrome Secondary to Tuberculosis of the Base of the Skull: A Case Report.
Cureus
November 2024
Internal Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, IND.
Collet-Sicard syndrome, resulting from the involvement of all four lower cranial nerves, is an extremely rare condition. This case report details a 69-year-old female patient who presented with classic signs and symptoms of lower cranial nerve palsies (IX, X, XI, and XII) and was subsequently diagnosed with Collet-Sicard syndrome secondary to tuberculosis at the base of the skull. A contrast-enhanced MRI of the neck revealed bone marrow edema in the clivus, occipital condyle, and C1 vertebra, along with diffuse surrounding soft tissue swelling and collection, findings consistent with tuberculosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!