AI Article Synopsis
- The paper discusses the creation of a diverse collection of unsymmetrical ureas using an 8-azabicyclo[3.2.1]octane structure as a base.
- The synthesis process involves using nortropane-8-carbonyl chlorides as essential intermediates.
- By reacting these intermediates with a small excess of amines, the researchers successfully produced 129 different ureas with high yields.
Article Abstract
This paper reports the preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold. The reported synthetic route uses nortropane-8-carbonyl chlorides as key intermediates that, when treated with a slight excess of amine, give the corresponding ureas in high yield (129 examples).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086471 | PMC |
| http://dx.doi.org/10.1021/cc800068k | DOI Listing |
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