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First-line immune-based combinations or sunitinib in favorable-risk metastatic renal cell carcinoma: a real-world retrospective comparison from the ARON-1 study.
Cancer Immunol Immunother
January 2025
Oncology Unit, Macerata Hospital, Macerata, Italy.
Introduction: Renal cell carcinoma (RCC) is one of the most common types of urogenital cancer. The introduction of immune-based combinations, including dual immune-checkpoint inhibitors (ICI) or ICI plus tyrosine kinase inhibitors (TKIs), has radically changed the treatment landscape for metastatic RCC, showing varying efficacy across different prognostic groups based on the International Metastatic RCC Database Consortium (IMDC) criteria.
Materials And Methods: This retrospective multicenter study, part of the ARON-1 project, aimed to evaluate the outcomes of favorable-risk metastatic RCC patients treated with immune-based combinations or sunitinib.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Afe Babalola University, Ado-Ekiti, Nigeria.
Background: Prolonged exposure to LED-light has been associated with impaired sleep quality and pathogenesis of various diseases, including Alzheimer's Disease (AD). Red light therapy has been indicated as a non-invasive way of reducing anxiety, mood and sleep optimization in neurodegenerative disorders but its endogenous mechanisms are insufficiently comprehended. Hence, we assessed the effects of scheduled red-light exposure on clock genes-Bmal1 and Per 1 expression, feacal boli frequency, and anxiety-like responses in prolonged LED-light exposed rats.
View Article and Find Full Text PDFUnlocking ABA's role in rice cold tolerance: insights from Zhonghua 11 and Kasalath.
Theor Appl Genet
January 2025
College of Agriculture, Hunan Agricultural University, Changsha, 410128, Hunan, China.
Unraveling key ABA pathways, including OsWRKY71-OsABA8ox1 and OsbZIP73-OsNCED5, provides valuable insights for improving cold tolerance in rice breeding for cold-prone regions. Cold stress limits rice (Oryza sativa L.) production in cooler climates.
View Article and Find Full Text PDFExploring the relationship between electrophysiological measures of the electrically evoked auditory brainstem response and speech perception outcomes post-cochlear implantation.
Eur Arch Otorhinolaryngol
January 2025
Department of Otolaryngology, China-Japan Friendship Hospital, Beijing, China.
Objectives: This study examined the relationships between electrophysiological measures of the electrically evoked auditory brainstem response (EABR) with speech perception measured in quiet after cochlear implantation (CI) to identify the ability of EABR to predict postoperative CI outcomes.
Methods: Thirty-four patients with congenital prelingual hearing loss, implanted with the same manufacturer's CI, were recruited. In each participant, the EABR was evoked at apical, middle, and basal electrode locations.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: The prevalence of sepsis and delirium in the elderly is a risk factor for subsequent diagnosis of Alzheimer's disease and related dementias (ADRD). Post-sepsis impairments include changes in memory, attention, emotional function, and neuromuscular strength. Studies have shown a link between the prolonged activation of microglia after infection.
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