In a recent landmark trial of bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) isolates, vancomycin MICs were >or=1 microg/ml for only 16% of the isolates, and accessory gene regulator (agr) function as measured by delta-hemolysin activity was absent or reduced in only 28.1% of the isolates. This clinical study did not capture a population of MRSA isolates predictive of vancomycin treatment failure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533503 | PMC |
| http://dx.doi.org/10.1128/AAC.00357-08 | DOI Listing |
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