Background: It is customary to assume that pre-analytical variation is negligible if all pre-analytical sources of variation have been standardised. The aim of this study was to quantify the pre-analytical variation of some haematological quantities frequently measured in clinical laboratories.
Methods: The experimental design considers different sources of pre-analytical variation that usually occur day-to-day for samples from patients.
Results: The results demonstrate that for concentrations of erythrocytes, haemoglobin, leukocytes, neutrophilocytes (segmented) and lymphocytes, and for the volume fraction of erythrocytes ("packed cell volume") in blood, the pre-analytical variance is not negligible.
Conclusions: We suggest that these variances should be taken into account when estimating the uncertainty of measurement for patient results.
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| http://dx.doi.org/10.1515/CCLM.2008.229 | DOI Listing |
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