AI Article Synopsis
- - The study aimed to establish normal metabolic ratios in the pons of healthy adult Chinese individuals using proton magnetic resonance spectroscopy (1HMRS).
- - Researchers scanned 80 healthy subjects aged 21 to 60, divided into four age groups, and measured ratios of key metabolites, finding the highest values in the 41-50 age group.
- - Results showed that the ratios of N-acetylaspartate/creatine-phosphocreatine, N-acetylaspartate/choline, and choline/creatine were consistent across different ages and genders, indicating no correlation with these factors.
Article Abstract
Objective: To determine the normal mean reference normal value for metabolic ratios in the pons of healthy adult Chinese subjects by using proton magnetic resonance spectroscopy (1HMRS).
Materials And Methods: Eighty healthy Chinese subjects, ranging in age from 21 to 60 years, were divided into four groups, each containing 20 subjects per decade. The pons of every subject was scanned on single-voxel 1HMRS by using the point-resolved proton spectroscopy sequence (PRESS) with echo time (TE)=144 ms and repetition time (TR)=1500 ms.
Results: The total mean ratios of N-acetylasparate/creatine-phosphocreatine (NAA/Cr), NAA/choline-containing compounds (Cho) and Cho/Cr in subjects ranging from 21 to 60 years were 2.13+/-0.07, 1.22+/-0.11 and 1.81+/-0.09 respectively. The highest metabolite ratios were seen in the 41-50 year group. There was no significant difference with respect to age or gender.
Conclusions: The ratios of NAA/Cr, NAA/Cho or Cho/Cr in the pons did not correlate with the age or gender of healthy subjects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.brainres.2008.06.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rotational Locking of Charged Microparticles in Quadrupole Ion Traps.
Phys Rev Lett
December 2024
Laboratoire De Physique de l'École Normale Supérieure, ENS, PSL, CNRS, Sorbonne Université, Université de Paris, 24 rue Lhomond, 75005 Paris, France.
Electric quadrupole traps are a leading technology for suspending charged objects ranging in size from single protons to atomic and molecular ions, and even to nano- and micron-sized bodies. If the levitated objects' charge distribution contains multipoles, the time-dependent trapping fields can significantly impact its rotational motion. Here, we experimentally observe the transition from librational motion to a regime where a microparticle rotates in sync with the trap drive.
View Article and Find Full Text PDFAssociation between Bioelectrical Impedance Parameters, Magnetic Resonance Imaging Muscle Parameters, and Fatty Liver Severity in Children and Adolescents.
Gut Liver
January 2025
Department of Radiology, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
Background/aims: To evaluate the associations between pediatric fatty liver severity, bioelectrical impedance analysis (BIA), and magnetic resonance imaging parameters, including total psoas muscle surface area (tPMSA) and paraspinal muscle fat (PMF).
Methods: Children and adolescents who underwent BIA and liver magnetic resonance imaging between September 2022 and November 2023 were included. Linear regression analyses identified predictors of liver proton density fat fraction (PDFF) including BIA parameters, tPMSA, and PMF.
Evaluation of Brain Impairment Using Proton Exchange Rate MRI in a Kainic Acid-Induced Rat Model of Epilepsy.
Mol Imaging Biol
January 2025
Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Purpose: Proton exchange rate (K) is a valuable biophysical metric. K MRI may augment conventional structural MRI by revealing brain impairments at the molecular level. This study aimed to investigate the feasibility of K MRI in evaluating brain injuries at multiple epilepsy stages.
View Article and Find Full Text PDFGenome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.
Nat Commun
January 2025
Folkhälsan Research Center, Helsinki, Finland.
Dissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular insights into kidney function and open possibilities for causal assessment of urinary metabolites with risk factors and disease outcomes. Proton nuclear magnetic resonance metabolomics provides a high-throughput means for urinary metabolite profiling, as widely applied for blood biomarker studies. Here we report a genome-wide association study meta-analysed for 3 European cohorts comprising 8,011 individuals, covering both people with type 1 diabetes and general population settings.
View Article and Find Full Text PDFPrognostic significance of total choline on in-vivo proton MR spectroscopy for prediction of late recurrence in patients with hormone receptor-positive, HER2-negative early breast cancer.
PLoS One
January 2025
Department of General Surgery, Breast Cancer Center, Gachon University Gil Medical Center, Incheon, Republic of Korea.
Purpose: In-vivo proton magnetic resonance spectroscopy (MRS) is a non-invasive method of analyzing choline metabolism that has been used to predict breast cancer prognosis. A strong choline peak may be a surrogate for aggressive tumor biology but its clinical relevance is unclear. The present study assessed whether total choline (tCho), as measured by proton MRS, can predict late recurrence in patients with hormone receptor (HR)-positive, HER2-negative early breast cancer.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!