[Inhibition of mutagen activity of colon metabolites by normal microbiocenosis].

Ames bacterial test system on strains Salmonella typhimurim TA 98 and TA 100 was used the detection of mutagen activity of the fecal extracts from 52 persons. Preliminary bacteriological analysis a qualitative and quantitative compound of intestinal microbiocenosis was investigated. Data of microbial maps has allowed to part a surveyed contingent on two groups, the first, consisting of 12 persons, without the expressed microecological deflections of standard content of the basic representatives of a resident microflora, and, the second, consisting of 40 persons, with the significant depression of population level of Bifidobacterium and Lactobacillus at fecal specimens. It is shown, that depression on 2 - 3 Ig of standard population levels of Bifidobacterium and Lactobacillus at fecal specimens leads to rising of a mutagen activity of fecal extracts. Correlation between a qualitative and quantitative compound of Escherichia coli and mutagen activity of colon extracts is not established. Enzymatic products of fecalase, received from colon extracts with the high content of Bifidobacterium and Lactobacillus considerably reduced the expressed mutagen effect of straight mutagen Nitrozo-guanidin and Nitrozo-methylurea.