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Differentiating multiple sclerosis with predominant spinal cord and optic nerve involvement from other autoimmune demyelinating diseases using B cell immunophenotyping and gene expression profiling.
Mult Scler Relat Disord
December 2024
Istanbul University, Aziz Sancar Institute for Experimental Medical Research, Department of Neuroscience, Istanbul, Turkiye.
Objective: Multiple sclerosis (MS) may present with predominant involvement of the spinal cord and optic nerve (MS/w-SCON) and mimic other autoimmune inflammatory demyelinating disorders (AIDD) such as neuromyelitis optica spectrum disorder (NMOSD), and relapsing inflammatory optic neuritis (RION). Thus, biomarkers are required for effective differential diagnosis of AIDD.
Methods: Patients with MS/w-SCON (n = 20), MS without involvement of SCON (MS/wo-SCON) (n = 22), NMOSD (n = 16), RION (n = 15) and healthy individuals (n = 21) were included.
Eye diseases remain a significant global health concern, with trace elements crucial in maintaining ocular health and preventing ocular disorders. In ocular health, trace elements have been recognized as critical factors influencing the development and progression of multiple eye diseases. In this study, we conducted a thorough literature search through PubMed to acquire data concerning different eye diseases associated with trace elements.
View Article and Find Full Text PDFTesting the Ability and Limitations of ChatGPT to Generate Differential Diagnoses from Transcribed Radiologic Findings.
Radiology
October 2024
From the Department of Radiological Sciences, UCI Medical Center, University of California, Irvine, 101 The City Dr S, Orange, CA 92868 (S.H.S., K.H., G.C., R. Hill, J.T., R. Houshyar, V.Y., M.T.); Anaheim, Calif (L.Y.); and Division of Research, Kaiser Permanente of Northern California, Pleasanton, Calif (A.L.N.).
Background The burgeoning interest in ChatGPT as a potentially useful tool in medicine highlights the necessity for systematic evaluation of its capabilities and limitations. Purpose To evaluate the accuracy, reliability, and repeatability of differential diagnoses produced by ChatGPT from transcribed radiologic findings. Materials and Methods Cases selected from a radiology textbook series spanning a variety of imaging modalities, subspecialties, and anatomic pathologies were converted into standardized prompts that were entered into ChatGPT (GPT-3.
View Article and Find Full Text PDFEducation Research: Competency-Based EEG Education: An Online Routine EEG Examination for Adult and Child Neurology Residents.
Neurol Educ
December 2023
From the Division of Epilepsy (F.A.N.), Department of Neurology, Washington University School of Medicine, St. Louis, MO; Department of Neurology (F.A.N., S.V.Y.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Internal Medicine (H.G.), Wake Forest University School of Medicine, Winston-Salem, NC; Division of Epilepsy (R.K.), Department of Neurology, Louisiana State University Health Shreveport; Department of Neurology (R.M.), Emory University School of Medicine, Atlanta, GA; Department of Neurosurgery (S.R.), University Hospital Erlangen; Department of Neurosurgery (S.R.), University Hospital Halle (Saale), Germany; Department of Neurology (W.O.T.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.E.S.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Clinical Neurophysiology (S.B.), Danish Epilepsy Center, Dianalund and Aarhus University Hospital; and Department of Clinical Medicine (S.B.), Aarhus University, Denmark.
Background And Objectives: We recently published expert consensus-based curricular objectives for routine EEG (rEEG) interpretation for adult and child neurology residents. In this study, we used this curriculum framework to develop and validate an online, competency-based, formative and summative rEEG examination for neurology residents.
Methods: We developed an online rEEG examination consisting of a brief survey and 30 multiple-choice questions covering EEG learning objectives for neurology residents in 4 domains: normal, abnormal, normal variants, and artifacts.
Pulsed Field Ablation to Treat Paroxysmal Atrial Fibrillation: Safety and Effectiveness in the AdmIRE Pivotal Trial.
Circulation
October 2024
Texas Cardiac Arrhythmia Research Foundation, Austin (A.N.).
Background: Evidence from clinical trials of early pulsed field ablation (PFA) systems in treating atrial fibrillation has demonstrated their promising potential to reduce complications associated with conventional thermal modalities while maintaining efficacy. However, the lack of a fully integrated mapping system, a staple technology of most modern electrophysiology procedures, poses limitations in lesion creation and workflow options. A novel variable-loop PFA catheter integrated with an electroanatomic mapping system has been developed that allows for real-time nonfluoroscopic procedural guidance and lesion indexing as well as feedback of tissue-to-catheter proximity.
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