Introduction: Dermoscopy began in 1663, and until 1971 was used to diagnose skin lesions.
Objective: To measure the correlation between simple observation and dermoscopy to diagnose pigmented skin lesions.
Methods: The study was conducted in Centro Médico Nacional La Raza. Sixty-eight patients with pigmented skin lesions were included. Participants were randomly examined by two dermatologists blinded to the study. Both dermatologists did simple observations and dermoscopy. Every participant was diagnosed using both procedures and by both doctors. A skin biopsy was obtained for pathological study.
Results: Kappa index of agreement to diagnose malignancy of the skin lesion between simple observation and histology was 0.69 (95 % CI 0.44, 0.93); the dermoscopy/histology Kappa index was 0.73 (95 % CI 0.60, 0.87). 75 % of positive results were obtained by using dermoscopy, compared to 63.9 % obtained by simple observation (p = 0.12). Simple observation and dermoscopy showed 94.44 % and 90.38 % sensitivity, specificity was 73.33 and 82.92 % and test accuracy was 84.84 and 87.09 % respectively.
Conclusions: Dermoscopy is a non-invasive technique with acceptable specificity and superior than simple observation to diagnose pigmented skin lesions.
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Biomed Phys Eng Express
January 2025
University of Gothenburg, Bruna stråket 13, Goteborg, 405 30, SWEDEN.
Dual-polarity readout is a simple and robust way to mitigate Nyquist ghosting in diffusion-weighted echo-planar imaging but imposes doubled scan time. We here propose how dual-polarity readout can be implemented with little or no increase in scan time by exploiting an observed b-value dependence and signal averaging. The b-value dependence was confirmed in healthy volunteers with distinct ghosting at low b-values but of negligible magnitude at b = 1000 s/mm2.
View Article and Find Full Text PDFPLoS One
January 2025
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America.
The extrusion bioprinting of collagen material has many applications relevant to tissue engineering and regenerative medicine. Freeform Reversible Embedding of Suspended Hydrogels (FRESH) technology is capable of 3D printing collagen material with the specifications and details needed for precise tissue guidance, a crucial requirement for effective tissue repair. While FRESH has shown repeated success and reliability for extrusion printing, the mechanical properties of completed collagen prints can be improved further by post-print crosslinking methodologies.
View Article and Find Full Text PDFRev Sci Instrum
January 2025
J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, Texas 77843, USA.
Ignition of the lubricating fluid in a mechanical system is a highly undesirable and unsafe condition that can arise from the elevated temperatures and pressures to which the lubricant is subjected. It is therefore important to understand the fundamental chemistry behind its ignition to predict and prevent this condition. Lubricating oils, particularly those with a mineral oil base, are very complex mixtures of thousands of hydrocarbons.
View Article and Find Full Text PDFJMIR Hum Factors
January 2025
School of Nursing, National Taipei University of Nursing and Health Sciences, Room B631, No. 365, Ming-te Road, Peitou District, Taipei City, 11219, Taiwan, 886 2 28227101 ext 3186.
Background: Colonoscopy is the standard diagnostic method for colorectal cancer. Patients usually receive written and verbal instructions for bowel preparation (BP) before the procedure. Failure to understand the importance of BP can lead to inadequate BP in 25%-30% of patients.
View Article and Find Full Text PDFOral Dis
January 2025
Laboratory of Clinical Pharmaceutics & Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Objectives: To externally validate a clinical prediction model for surgical site infection (SSI) after lower third molar (L3M) surgery and evaluate its clinical usefulness.
Methods: We conducted a retrospective cohort study of patients who underwent L3M surgery at Hokkaido University Hospital. The study was designed to evaluate the historical and methodological transportability.
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