The main characteristic of all types of sleep disordered breathing (SDB) is partial or complete obstruction in the upper airway. Patency of the pharyngeal airway is maintained by two opposing forces: negative intraluminal pressure and the activity of the upper airway musculature. Different anatomical abnormalities can disrupt this delicate balance with resultant compromise of the upper airway. Thus, the main goal of the medical and surgical therapy is to alleviate this obstruction and increase airway patency. If multilevel obstruction is noted, multilevel-surgery is needed. It can be done as one-stage or multi-stage procedure which depends on the current patient state and surgical skill. Technical developments and their implementation in everyday surgical practice made some of the surgical methods for SDB treatment more convinient for the patient. Surgery can be performed in ambulatory facility and the procedures are repeatable with no adverse effects which significantly decreases the postoperative morbidity. Almost all surgical techniques for SDB treatment have good results in properly selected patients. That is why the key for the successful SDB treatment is a proper multidisciplinary diagnostic algorithm and a team work.
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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, which arises in the upper airway mucosa, is particularly aggressive, with nearly half of patients succumbing to the disease within five years and limited response to immune checkpoint inhibitors compared to other cancers. There is a need to further explore the complex immune landscape in HPV-negative HNSCC to identify potential therapeutic targets.
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Graduate School of Data Science, Seoul National University, Seoul, Republic of Korea.
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Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
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View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.
Dry powder inhalers (DPI's) are becoming increasingly popular due to growing interest in pulmonary drug delivery and their performance is the net result of a series of processes carried out during the formulation development and manufacturing process such as excipient selection, blending, milling, filling, and spray drying. To reach the small airways of the deep lung, the active pharmaceutical ingredients (API) particles need to have an aerodynamic diameter of 1-5 μm to avoid impaction and particle sedimentation in the upper respiratory tract, and due to this small particle size, the powder becomes highly cohesive resulting in poor flow. Therefore, API is usually blended with a coarse carrier to improve flowability, and due to its large size, it is more fluidizable than the micronized drug.
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