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| http://dx.doi.org/10.1208/s12248-008-9046-3 | DOI Listing |
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The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine.
Pharmaceuticals (Basel)
January 2025
Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA.
There is clinical concern about the combined use of alcohol and opiates. Several lines of evidence support an interaction between alcohol and the endogenous opioid system. Thus, we hypothesized that ethanol, by causing the release of opioid peptides, may sensitize the system to the action of exogenous opioids such as morphine.
View Article and Find Full Text PDFN-Palmitoylethanolamide enhances antinociceptive effect of tramadol in neuropathic rats.
Biomed Pharmacother
January 2025
Laboratory 7, "Pain and Analgesia", Department of Pharmacobiology, Center for Research and Advanced Studies (CINVESTAV), Sede Sur, Mexico City, Mexico.
The efficacy of opioids in the treatment of chronic pain is limited; however, the adverse effects they produce are considerable. N-palmitoylethanolamide (PEA), a bioactive lipid mediator with structural similarities to endocannabinoids, has exhibited notable anti-inflammatory and analgesic effects in preclinical models. The objective of this study was to investigate the antinociceptive properties, motor coordination (MC), and constipation effects of tramadol and PEA in combination within a neuropathic pain model.
View Article and Find Full Text PDFSuccessful analgesic treatment with continuous sacral epidural ethanol injection therapy for anal pain caused by multiple metastases of malignant pheochromocytoma.
JA Clin Rep
December 2024
Division of Operation Room, Nagoya University Hospital, Nagoya, Aichi, Japan.
Background: Anal and perineum pain caused by malignant tumor invasion is often difficult to control with opioids. Continuous sacral epidural ethanol injection therapy is less likely to cause bladder and rectal disturbances, making it a suitable treatment option for patients with preserved voiding function.
Case Presentation: A 45-year-old woman with multiple metastases of malignant pheochromocytoma suffered severe anal pain that worsened, especially when sitting, and was unresponsive to opioid rescue therapy.
Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking.
Pharmacol Biochem Behav
February 2025
Department of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA. Electronic address:
Mu-opioid receptors (MORs) in the amygdala and striatum are important in addictive and rewarding behaviors. The transcription factor Foxp2 is a genetic marker of intercalated (ITC) cells in the amygdala and a subset of striatal medium spiny neurons (MSNs), both of which express MORs in wild-type mice and are neuronal subpopulations of potential relevance to alcohol-drinking behaviors. For the current series of studies, we characterized the behavior of mice with genetic deletion of the MOR gene Oprm1 in Foxp2-expressing neurons (Foxp2-Cre/Oprm1).
View Article and Find Full Text PDFThe use of prescription medication and other drugs by New Zealand drivers with illegal blood alcohol levels.
Traffic Inj Prev
November 2024
Forensic Specialised Analytical Services (F-SAS), Institute of Environmental Science and Research (ESR), Wellington, New Zealand.
Objective: This study examined the prevalence of the use of prescription medicines and other drugs by a selected subgroup of New Zealand drivers. The use of potentially impairing prescription drugs by the driving population is largely unknown. The population studied was drivers who were stopped by police, failed a breath alcohol test, elected to provide a blood sample for laboratory analysis, and had blood alcohol levels exceeding the legal limit.
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