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Are corticosteroids safe in adolescent and adult patients with infectious mononucleosis? A retrospective cohort study.
Enferm Infecc Microbiol Clin (Engl Ed)
January 2025
Department of Internal Medicine, Complejo Hospitalario Universitario, University of Santiago de Compostela, Spain. Electronic address:
Background And Aim: The use of systemic corticosteroids during Epstein-Barr virus (EBV)-induced infectious mononucleosis is a controversial but widespread practice. We aimed to investigate the frequency of complications in adolescents and adults with infectious mononucleosis in relation to the use of corticosteroids.
Methods: We reviewed the clinical records of 396 patients admitted to the hospital with infectious mononucleosis (52.
Experimental infection and co-infection with Chinese strains of Ehrlichia canis and Babesia vogeli in intact and splenectomized dogs: Insights on clinical, hematologic and treatment responses.
Vet Parasitol
November 2023
College of Veterinary Medicine, Auburn University, Auburn, AL, USA. Electronic address:
Animal infection models are crucial for studying various aspects of Ehrlichia canis infections. To understand the pathogenesis of the first Chinese isolate of E. canis and simulate the natural progression of canine ehrlichiosis, we developed a model with 18 Beagle dogs that consisted of E.
View Article and Find Full Text PDFInfluenza enhances host susceptibility to non-pulmonary invasive infections.
Virulence
December 2023
Division of Basic Biomedical Sciences, The Sanford School of Medicine of the University of South Dakota, Vermillion, SD, USA.
(group A streptococcus; GAS) causes a variety of invasive diseases (iGAS) such as bacteremia, toxic shock syndrome, and pneumonia, which are associated with high mortality despite the susceptibility of the bacteria to penicillin . Epidemiologic studies indicate that respiratory influenza virus infection is associated with an increase in the frequency of iGAS diseases, including those not directly involving the lung. We modified a murine model of influenza A (IAV)-GAS superinfection to determine if viral pneumonia increased the susceptibility of mice subsequently infected with GAS in the peritoneum.
View Article and Find Full Text PDFFrom Infection to Death: An Overview of the Pathogenesis of Visceral Leishmaniasis.
Pathogens
July 2023
Departament of Physiotherapy, Centro Universitário Uninovafapi, Rua Vitorino Orthiges Fernandes, 6123-Uruguai, Teresina 64073-505, PI, Brazil.
Kala-azar, also known as visceral leishmaniasis (VL), is a disease caused by and . Patients experience symptoms such as fever, weight loss, paleness, and enlarged liver and spleen. The disease also affects immunosuppressed individuals and has an overall mortality rate of up to 10%.
View Article and Find Full Text PDFIn vivo killing of primary HIV-infected cells by peripheral-injected early memory-enriched anti-HIV duoCAR T cells.
JCI Insight
November 2022
Caring Cross, Gaithersburg, Maryland, USA.
HIV-specific chimeric antigen receptor-T cell (CAR T cell) therapies are candidates to functionally cure HIV infection in people with HIV (PWH) by eliminating reactivated HIV-infected cells derived from latently infected cells within the HIV reservoir. Paramount to translating such therapeutic candidates successfully into the clinic will require anti-HIV CAR T cells to localize to lymphoid tissues in the body and eliminate reactivated HIV-infected cells such as CD4+ T cells and monocytes/macrophages. Here we show that i.
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