AI Article Synopsis
- The study examined 54 asthmatic patients to explore the link between inflammatory cell recruitment in the airways and the late-phase asthmatic reaction following allergen exposure.
- Five patients with a late-phase response showed a significant increase in eosinophils in bronchoalveolar lavage samples taken 4 hours after allergen challenge.
- Only patients experiencing a late-phase response exhibited increased airway responsiveness before bronchoalveolar lavage, suggesting a correlation between eosinophil recruitment and airway sensitivity following allergen exposure.
Article Abstract
To determine whether a link exists between the recruitment of inflammatory cells in the airways and the development of the late-phase asthmatic reaction, we studied with bronchoalveolar lavage 54 asthmatic patients either at baseline (10 patients) or 4 h (11 patients), 24 h (13 patients), and 72 h (20 patients) after allergen inhalation challenge. Among the patients studied 4 h after allergen challenge, five were known to have a late-phase asthmatic response and showed a significant increase in the number and percentage of eosinophils in bronchoalveolar lavage compared with either patients without late-phase response (p less than 0.05) or unchallenged patients (p less than 0.01). Both the number and the percentage of eosinophils in bronchoalveolar lavage were also increased (p less than 0.05) in patients without a late-phase asthmatic reaction studied 24 h but not in those studied 4 h after allergen challenge. The numbers and the percentages of macrophages, neutrophils, or lymphocytes did not differ significantly among the different groups of patients. Of the patients studied 4 and 24 h after allergen challenge, only those with a late-phase asthmatic response showed an increased airway responsiveness to methacholine 1 h before bronchoalveolar lavage. We conclude that the development of the late-phase asthmatic response to allergen inhalation challenge and the allergen-induced increase in airway responsiveness are associated with an early recruitment of eosinophils in the airways.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1164/ajrccm/144.2.379 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analyzing phenotypes post-exposure in allergic rhinitis in the environmental exposure unit.
Ann Allergy Asthma Immunol
November 2024
Allergy Research Unit, Kingston Health Sciences Centre - Kingston General Hospital Site, Kingston, Ontario, Canada; Department of Medicine, Queen's University, Kingston, Ontario, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. Electronic address:
Background: Previous studies have defined clinical phenotypes of allergic rhinitis (AR) after allergen exposure using the time course of the total nasal symptom score (TNSS).
Objective: To validate previously proposed AR phenotypes across different allergens (birch, grass, ragweed, and house dust mite) after exposure in the environmental exposure unit.
Methods: The Analyzing Phenotypes Post-Exposure in Allergic Rhinitis (APPEAR) database comprises 153 participants from environmental exposure unit studies conducted between 2010 and 2021 by Kingston Allergy Research.
Enrollment of underserved racial and ethnic populations in pediatric asthma clinical trials.
J Allergy Clin Immunol Glob
November 2024
Division of Child Health Research and Policy, Harvard Medical School & Harvard Pilgrim Health Care Institute, Boston, Mass.
Background: The existing data on enrollment trends of historically underserved racial and ethnic children in clinical trials are limited.
Objective: We sought to evaluate documentation and representation of race and ethnicity in pediatric asthma clinical trials in the United States.
Methods: This is a cross-sectional study of United States-based interventional trials studying pediatric asthma that were completed between 2008 and 2022 and registered on ClinicalTrials.
Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits.
Biol Psychiatry
May 2024
Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands. Electronic address:
Article Synopsis
- Researchers conducted a study on vocabulary development in children, looking specifically at how genetic factors influence both expressive and receptive vocabulary sizes as children grow.
- The study involved nearly 38,000 parental reports from children of European descent and analyzed vocabulary measures at different developmental stages, assessing various genetic correlations.
- Findings indicated that early vocabulary is somewhat heritable and that there's genetic overlap with literacy skills, but a strong link to intelligence and ADHD appears later during toddlerhood.
Targeting the translationally controlled tumor protein by a monoclonal antibody improves allergic airway inflammation in mice.
Biomed Pharmacother
December 2023
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, the Republic of Korea. Electronic address:
Secretion of translationally controlled tumor protein (TCTP) was found in body fluids during the late phase of allergic reactions, implicating TCTP in allergic diseases. Furthermore, blocking TCTP has been shown to be helpful in treating asthma and allergies in animal models. The objectives of this study were to produce anti-TCTP monoclonal antibodies (mAbs), test their ability to inhibit the cytokine-like function of dimeric TCTP (dTCTP) in vitro and to assess their therapeutic effects in a murine model of ovalbumin (OVA)-induced airway inflammation.
View Article and Find Full Text PDFEvaluation of the reproducibility of responses to nasal allergen challenge and effects of inhaled nasal corticosteroids.
Clin Exp Allergy
November 2023
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Background: Similar immune responses in the nasal and bronchial mucosa implies that nasal allergen challenge (NAC) is a suitable early phase experimental model for drug development targeting allergic rhinitis (AR) and asthma. We assessed NAC reproducibility and the effects of intranasal corticosteroids (INCS) on symptoms, physiology, and inflammatory mediators.
Methods: 20 participants with mild atopic asthma and AR underwent three single blinded nasal challenges each separated by three weeks (NCT03431961).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!